Hypolipidemic Activity of Symplocos Cochinchinensis S. Moore Leaves in Hyperlipidemic Rats

Overview

Journal J Nat Med

Publisher Springer

Date 2011 Jun 18

PMID 21681640

Citations 5

Authors

Christudas Sunil

Savarimuthu Ignacimuthu

Chidambaram Kumarappan

Affiliations

Soon will be listed here.

Abstract

The hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves was studied in Triton WR-1339- and high fat diet-induced hyperlipidemic rats. In Triton WR-1339-induced hyperlipidemic rats, the hexane extract (250 and 500 mg/kg) exerted a significant (P < 0.01) lipid-lowering effect compared to ethyl acetate and methanol extracts, as assessed by the reversal of the plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). In high fat diet-fed hyperlipidemic rats, the hexane extract (250 and 500 mg/kg) caused the lowering of lipid levels in the plasma and liver. The hypolipidemic activity of S. cochinchinensis leaves was compared with fenofibrate, a known lipid-lowering drug, in both models.

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