Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes SCSIO15079 with Antihyperlipidemic Activities

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2022 Apr 21

PMID 35447932

Authors

Ziqi Su

Kunlong Li

Xiaowei Luo

Yongyan Zhu

Shao-Yu Mai

Quanhong Zhu

Bin Yang

Xuefeng Zhou

Huaming Tao

Affiliations

Soon will be listed here.

Abstract

Six new aromatic acids (-) and three new leucine derivatives containing an unusual oxime moiety (-) were isolated and identified from the deep-sea-derived actinomycetes strain SCSIO15079, together with two known compounds (-). The structures of - including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds - were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds and , with the most potent inhibitory activity on intracellular lipid accumulation at 10 μM, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied.

Citing Articles

Use of soil actinomycetes for pharmaceutical, food, agricultural, and environmental purposes.

Nazari M, Machado B, Marchezi G, Crestani L, Ferrari V, Colla L 3 Biotech. 2022; 12(9):232.

PMID: 35996673 PMC: 9391553. DOI: 10.1007/s13205-022-03307-y.

References

Kromhout D, Bosschieter E, de Lezenne Coulander C . The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med. 1985; 312(19):1205-9. DOI: 10.1056/NEJM198505093121901. View

Shin H, Lee H, Lee J, Shin J, Lee M, Lee H . Violapyrones H and I, new cytotoxic compounds isolated from Streptomyces sp. associated with the marine starfish Acanthaster planci. Mar Drugs. 2014; 12(6):3283-91. PMC: 4071576. DOI: 10.3390/md12063283. View

Lee J, Yoo I, Kim W . Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus. Biol Pharm Bull. 2007; 30(4):795-7. DOI: 10.1248/bpb.30.795. View

Murray M, Dordevic A, Bonham M, Ryan L . Do marine algal polyphenols have antidiabetic, antihyperlipidemic or anti-inflammatory effects in humans? A systematic review. Crit Rev Food Sci Nutr. 2017; 58(12):2039-2054. DOI: 10.1080/10408398.2017.1301876. View

Shang N, Zhang Z, Huang J, Wang L, Luo J, Yang J . Glycosylated piericidins from an endophytic streptomyces with cytotoxicity and antimicrobial activity. J Antibiot (Tokyo). 2018; 71(7):672-676. DOI: 10.1038/s41429-018-0051-1. View

Mi Y, Tan D, He Y, Zhou X, Zhou Q, Ji S . Melatonin Modulates lipid Metabolism in HepG2 Cells Cultured in High Concentrations of Oleic Acid: AMPK Pathway Activation may Play an Important Role. Cell Biochem Biophys. 2018; 76(4):463-470. DOI: 10.1007/s12013-018-0859-0. View

Hosomi R, Fukunaga K, Arai H, Kanda S, Nishiyama T, Yoshida M . Fish protein decreases serum cholesterol in rats by inhibition of cholesterol and bile acid absorption. J Food Sci. 2012; 76(4):H116-21. DOI: 10.1111/j.1750-3841.2011.02130.x. View

Liu D, Yang A, Wu C, Guo P, Proksch P, Lin W . Lipid-lowering effects of farnesylquinone and related analogues from the marine-derived Streptomyces nitrosporeus. Bioorg Med Chem Lett. 2014; 24(22):5288-93. DOI: 10.1016/j.bmcl.2014.09.049. View

El-Gendy M, El-Bondkly A . Production and genetic improvement of a novel antimycotic agent, saadamycin, against dermatophytes and other clinical fungi from endophytic Streptomyces sp. Hedaya48. J Ind Microbiol Biotechnol. 2010; 37(8):831-41. DOI: 10.1007/s10295-010-0729-2. View

10.

Pang X, Zhou X, Lin X, Yang B, Tian X, Wang J . Structurally various sorbicillinoids from the deep-sea sediment derived fungus Penicillium sp. SCSIO06871. Bioorg Chem. 2021; 107:104600. DOI: 10.1016/j.bioorg.2020.104600. View

11.

Xu X, He F, Zhang X, Bao J, Qi S . New mycotoxins from marine-derived fungus Aspergillus sp. SCSGAF0093. Food Chem Toxicol. 2012; 53:46-51. DOI: 10.1016/j.fct.2012.11.037. View

12.

Serban M, Colantonio L, Manthripragada A, Monda K, Bittner V, Banach M . Statin Intolerance and Risk of Coronary Heart Events and All-Cause Mortality Following Myocardial Infarction. J Am Coll Cardiol. 2017; 69(11):1386-1395. DOI: 10.1016/j.jacc.2016.12.036. View

13.

Sunil C, Ignacimuthu S, Kumarappan C . Hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves in hyperlipidemic rats. J Nat Med. 2011; 66(1):32-8. DOI: 10.1007/s11418-011-0548-4. View

14.

Luo X, Lin X, Tao H, Wang J, Li J, Yang B . Isochromophilones A-F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp. SCSIO 41011. J Nat Prod. 2018; 81(4):934-941. DOI: 10.1021/acs.jnatprod.7b01053. View

15.

Yokozawa T, Ishida A, Cho E, Nakagawa T . The effects of Coptidis Rhizoma extract on a hypercholesterolemic animal model. Phytomedicine. 2003; 10(1):17-22. DOI: 10.1078/094471103321648610. View

16.

Lee M, Yang H, Park K, Ma J . Lycopus lucidus Turcz. ex Benth. Attenuates free fatty acid-induced steatosis in HepG2 cells and non-alcoholic fatty liver disease in high-fat diet-induced obese mice. Phytomedicine. 2019; 55:14-22. DOI: 10.1016/j.phymed.2018.07.008. View

17.

Chen W, Zhang J, Qi X, Zhao K, Pang X, Lin X . -Terphenyls as Anti-HSV-1/2 Agents from a Deep-Sea-Derived sp. J Nat Prod. 2021; 84(11):2822-2831. DOI: 10.1021/acs.jnatprod.1c00400. View

18.

Andrade S, Saperia G, Berger M, Platt R . Effectiveness of antihyperlipidemic drug management in clinical practice. Clin Ther. 2000; 21(11):1973-87. DOI: 10.1016/S0149-2918(00)86743-0. View

19.

Momtazi-Borojeni A, Katsiki N, Pirro M, Banach M, Al Rasadi K, Sahebkar A . Dietary natural products as emerging lipoprotein(a)-lowering agents. J Cell Physiol. 2019; 234(8):12581-12594. DOI: 10.1002/jcp.28134. View

20.

Li Y, Sheng Y, Lu X, Guo X, Xu G, Han X . Isolation and purification of acidic polysaccharides from Agaricus blazei Murill and evaluation of their lipid-lowering mechanism. Int J Biol Macromol. 2020; 157:276-287. DOI: 10.1016/j.ijbiomac.2020.04.190. View