Quinolone Resistance-determining Region in the DNA Gyrase GyrA Gene of Escherichia Coli

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1990 Jun 1

PMID 2168148

Citations 320

Authors

H Yoshida

M Bogaki

M Nakamura

S Nakamura

Affiliations

Soon will be listed here.

Abstract

Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.

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