In Vivo Cell Death Mediated by Synthetic Ion Channels

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2011 Jun 18

PMID 21681307

Citations 5

Authors

Bryan A Smith

Megan M Daschbach

Seth T Gammon

Shuzhang Xiao

Sarah E Chapman

Caroline Hudson

Mark Suckow

David Piwnica-Worms

George W Gokel

W Matthew Leevy

Affiliations

Soon will be listed here.

Abstract

Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

Citing Articles

Recent Advances in Bioactive Artificial Ionophores.

Roy A, Talukdar P Chembiochem. 2021; 22(20):2925-2940.

PMID: 34043277 PMC: 8596773. DOI: 10.1002/cbic.202100112.

Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels.

Roy A, Joshi H, Ye R, Shen J, Chen F, Aksimentiev A Angew Chem Int Ed Engl. 2020; 59(12):4806-4813.

PMID: 31950583 PMC: 7093082. DOI: 10.1002/anie.201916287.

A halogen bond-mediated highly active artificial chloride channel with high anticancer activity.

Ren C, Ding X, Roy A, Shen J, Zhou S, Chen F Chem Sci. 2018; 9(17):4044-4051.

PMID: 29780533 PMC: 5935034. DOI: 10.1039/c8sc00602d.

Hydraphiles: a rigorously studied class of synthetic channel compounds with in vivo activity.

Negin S, Smith B, Unger A, Leevy W, Gokel G Int J Biomed Imaging. 2013; 2013:803579.

PMID: 23401675 PMC: 3562588. DOI: 10.1155/2013/803579.

Biomarkers and molecular probes for cell death imaging and targeted therapeutics.

Smith B, Smith B Bioconjug Chem. 2012; 23(10):1989-2006.

PMID: 22989049 PMC: 3477794. DOI: 10.1021/bc3003309.

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