When Orthologs Diverge Between Human and Mouse

Overview

Journal Brief Bioinform

Publisher Oxford University Press

Specialty Biology

Date 2011 Jun 17

PMID 21677033

Citations 43

Authors

Walid H Gharib

Marc Robinson-Rechavi

Affiliations

Soon will be listed here.

Abstract

Despite the common assumption that orthologs usually share the same function, there have been various reports of divergence between orthologs, even among species as close as mammals. The comparison of mouse and human is of special interest, because mouse is often used as a model organism to understand human biology. We review the literature on evidence for divergence between human and mouse orthologous genes, and discuss it in the context of biomedical research.

Citing Articles

A Comparative Analysis of Models for AAV-Mediated Gene Therapy for Inherited Retinal Diseases.

Alsalloum A, Gornostal E, Mingaleva N, Pavlov R, Kuznetsova E, Antonova E Cells. 2024; 13(20.

PMID: 39451224 PMC: 11506034. DOI: 10.3390/cells13201706.

Coexpression enhances cross-species integration of single-cell RNA sequencing across diverse plant species.

Passalacqua M, Gillis J Nat Plants. 2024; 10(7):1075-1080.

PMID: 38937637 PMC: 11266096. DOI: 10.1038/s41477-024-01738-4.

Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy.

Duan C, Ding C, Sun X, Mao S, Liang Y, Liu X Stem Cell Res Ther. 2024; 15(1):152.

PMID: 38816767 PMC: 11140964. DOI: 10.1186/s13287-024-03767-4.

Functional Divergence in Orthologous Transcription Factors: Insights from AtCBF2/3/1 and OsDREB1C.

Deng D, Guo Y, Guo L, Li C, Nie Y, Wang S Mol Biol Evol. 2024; 41(5).

PMID: 38723179 PMC: 11119335. DOI: 10.1093/molbev/msae089.

Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications.

Cerneckis J, Cai H, Shi Y Signal Transduct Target Ther. 2024; 9(1):112.

PMID: 38670977 PMC: 11053163. DOI: 10.1038/s41392-024-01809-0.

References

McGary K, Park T, Woods J, Cha H, Wallingford J, Marcotte E . Systematic discovery of nonobvious human disease models through orthologous phenotypes. Proc Natl Acad Sci U S A. 2010; 107(14):6544-9. PMC: 2851946. DOI: 10.1073/pnas.0910200107. View

Franco A, Malaguarnera R, Refetoff S, Liao X, Lundsmith E, Kimura S . Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proc Natl Acad Sci U S A. 2011; 108(4):1615-20. PMC: 3029699. DOI: 10.1073/pnas.1015557108. View

Pereira V, Waxman D, Eyre-Walker A . A problem with the correlation coefficient as a measure of gene expression divergence. Genetics. 2009; 183(4):1597-600. PMC: 2787443. DOI: 10.1534/genetics.109.110247. View

Knowles D, McLysaght A . Recent de novo origin of human protein-coding genes. Genome Res. 2009; 19(10):1752-9. PMC: 2765279. DOI: 10.1101/gr.095026.109. View

Suzuki Y, Iai M, Kamei A, Tanabe Y, Chida S, Yamaguchi S . Peroxisomal acyl CoA oxidase deficiency. J Pediatr. 2002; 140(1):128-30. DOI: 10.1067/mpd.2002.120511. View

Liao B, Zhang J . Low rates of expression profile divergence in highly expressed genes and tissue-specific genes during mammalian evolution. Mol Biol Evol. 2006; 23(6):1119-28. DOI: 10.1093/molbev/msj119. View

Elso C, Lu X, Morrison S, Tarver A, Thompson H, Thurkow H . Germline translocations in mice: unique tools for analyzing gene function and long-distance regulatory mechanisms. J Natl Cancer Inst Monogr. 2008; (39):91-5. DOI: 10.1093/jncimonographs/lgn008. View

Flicek P, Amode M, Barrell D, Beal K, Brent S, Chen Y . Ensembl 2011. Nucleic Acids Res. 2010; 39(Database issue):D800-6. PMC: 3013672. DOI: 10.1093/nar/gkq1064. View

Proux E, Studer R, Moretti S, Robinson-Rechavi M . Selectome: a database of positive selection. Nucleic Acids Res. 2008; 37(Database issue):D404-7. PMC: 2686563. DOI: 10.1093/nar/gkn768. View

10.

Waterston R, Lindblad-Toh K, Birney E, Rogers J, Abril J, Agarwal P . Initial sequencing and comparative analysis of the mouse genome. Nature. 2002; 420(6915):520-62. DOI: 10.1038/nature01262. View

11.

Liao B, Zhang J . Evolutionary conservation of expression profiles between human and mouse orthologous genes. Mol Biol Evol. 2005; 23(3):530-40. DOI: 10.1093/molbev/msj054. View

12.

Jimenez-Sanchez G, Childs B, Valle D . Human disease genes. Nature. 2001; 409(6822):853-5. DOI: 10.1038/35057050. View

13.

Yashiro K, Saijoh Y, Sakuma R, Tada M, Tomita N, Amano K . Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes. Genes Cells. 2000; 5(5):343-57. DOI: 10.1046/j.1365-2443.2000.00329.x. View

14.

Roux J, Robinson-Rechavi M . Age-dependent gain of alternative splice forms and biased duplication explain the relation between splicing and duplication. Genome Res. 2010; 21(3):357-63. PMC: 3044850. DOI: 10.1101/gr.113803.110. View

15.

Kassir Y, Rubin-Bejerano I, Mandel-Gutfreund Y . The Saccharomyces cerevisiae GSK-3 beta homologs. Curr Drug Targets. 2006; 7(11):1455-65. DOI: 10.2174/1389450110607011455. View

16.

Benton M, Donoghue P . Paleontological evidence to date the tree of life. Mol Biol Evol. 2006; 24(1):26-53. DOI: 10.1093/molbev/msl150. View

17.

Cappuzzo F . Erlotinib in gliomas: should selection be based on EGFR and Akt analyses?. J Natl Cancer Inst. 2005; 97(12):868-9. DOI: 10.1093/jnci/dji169. View

18.

Liu Z, Miner J, Yago T, Yao L, Lupu F, Xia L . Differential regulation of human and murine P-selectin expression and function in vivo. J Exp Med. 2010; 207(13):2975-87. PMC: 3005233. DOI: 10.1084/jem.20101545. View

19.

Su A, Wiltshire T, Batalov S, Lapp H, Ching K, Block D . A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A. 2004; 101(16):6062-7. PMC: 395923. DOI: 10.1073/pnas.0400782101. View

20.

Liu H, Chen C, Espinoza-Lewis R, Jiao Z, Sheu I, Hu X . Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function. J Biol Chem. 2011; 286(19):17029-38. PMC: 3089547. DOI: 10.1074/jbc.M111.234252. View