Order of Operations for Decoding Superior Colliculus Activity for Saccade Generation

Overview

Journal J Neurophysiol

Publisher American Physiological Society

Specialties Neurology
Physiology

Date 2011 Jun 17

PMID 21676934

Citations 11

Authors

Husam A Katnani

Neeraj J Gandhi

Affiliations

Soon will be listed here.

Abstract

To help understand the order of events that occurs when generating saccades, we simulated and tested two commonly stated decoding models that are believed to occur in the oculomotor system: vector averaging (VA) and center-of-mass. To generate accurate saccades, each model incorporates two required criteria: 1) a decoding mechanism that deciphers a population response of the superior colliculus (SC) and 2) an exponential transformation that converts the saccade vector into visual coordinates. The order of these two criteria is used differently within each model, yet the significance of the sequence has not been quantified. To distinguish between each decoding sequence and hence, to determine the order of events necessary to generate accurate saccades, we simulated the two models. Distinguishable predictions were obtained when two simultaneous motor commands are processed by each model. Experimental tests of the models were performed by observing the distribution of endpoints of saccades evoked by weighted, simultaneous microstimulation of two SC sites. The data were consistent with the predictions of the VA model, in which exponential transformation precedes the decoding computation.

Citing Articles

Rapid Input-Output Transformation between Local Field Potential and Spiking Activity during Sensation but not Action in the Superior Colliculus.

Bourrelly C, Massot C, Gandhi N J Neurosci. 2023; 43(22):4047-4061.

PMID: 37127365 PMC: 10255026. DOI: 10.1523/JNEUROSCI.2318-22.2023.

Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements.

Buonocore A, Tian X, Khademi F, Hafed Z Elife. 2021; 10.

PMID: 33955354 PMC: 8143798. DOI: 10.7554/eLife.64150.

Sensorimotor transformation elicits systematic patterns of activity along the dorsoventral extent of the superior colliculus in the macaque monkey.

Massot C, Jagadisan U, Gandhi N Commun Biol. 2019; 2:287.

PMID: 31396567 PMC: 6677725. DOI: 10.1038/s42003-019-0527-y.

Arousal Effects on Pupil Size, Heart Rate, and Skin Conductance in an Emotional Face Task.

Wang C, Baird T, Huang J, Coutinho J, Brien D, Munoz D Front Neurol. 2018; 9:1029.

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Visual attention is not deployed at the endpoint of averaging saccades.

Wollenberg L, Deubel H, Szinte M PLoS Biol. 2018; 16(6):e2006548.

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