Higher Micronutrient Intake is Associated with Human Papillomavirus-positive Head and Neck Cancer: a Case-only Analysis

Overview

Journal Nutr Cancer

Publisher Routledge

Specialties Nutritional Sciences
Oncology

Date 2011 Jun 14

PMID 21667401

Citations 12

Authors

Anna E Arthur

Sonia A Duffy

Gloria I Sanchez

Stephen B Gruber

Jeffrey E Terrell

James R Hebert

Emily Light

Carol R Bradford

Nisha J DSilva

Thomas E Carey

Gregory T Wolf

Karen E Peterson

Laura S Rozek

Affiliations

Soon will be listed here.

Abstract

No studies have investigated dietary differences between head and neck squamous cell carcinoma (HNSCC) patients with human papillomavirus (HPV)-positive tumors and patients with HPV-negative tumors. This study was designed to investigate the relationship between diet and HPV status in HNSCC patients. Cases of HNSCC were recruited from 2 clinical centers participating in the University of Michigan Head and Neck Specialized Program of Research Excellence (SPORE). HPV tissue genotyping was performed, and epidemiological and dietary data collected. Multivariable logistic regression tested whether pretreatment consumption of 12 selected micronutrients was significantly associated with HPV-positive status in 143 patients newly diagnosed with cancer of the oral cavity or pharynx. After controlling for age, sex, body mass index, tumor site, cancer stage, problem drinking, smoking, and energy intake, significant and positive associations were observed between vitamin A, vitamin E, iron, β-carotene, and folate intake and HPV-positive status (P(trend) < 0.05), suggesting that diet may be a factor in the improved prognosis documented in those with HPV-positive HNSCC. Dietary differences by HPV status should be considered in prognostic studies to better understand the influence of diet on HNSCC survival.

Citing Articles

Dietary Carotenoids in Head and Neck Cancer-Molecular and Clinical Implications.

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Molecular Tumor Subtypes of HPV-Positive Head and Neck Cancers: Biological Characteristics and Implications for Clinical Outcomes.

Qin T, Li S, Henry L, Liu S, Sartor M Cancers (Basel). 2021; 13(11).

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The prevalence of human papillomavirus in oropharyngeal cancer in a New Zealand population.

Lucas-Roxburgh R, Benschop J, Lockett B, van den Heever U, Williams R, Howe L PLoS One. 2017; 12(10):e0186424.

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Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma.

Albergotti W, Davis K, Abberbock S, Bauman J, Ohr J, Clump D Oral Oncol. 2016; 60:55-60.

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Subtypes of HPV-Positive Head and Neck Cancers Are Associated with HPV Characteristics, Copy Number Alterations, PIK3CA Mutation, and Pathway Signatures.

Zhang Y, Koneva L, Virani S, Arthur A, Virani A, Hall P Clin Cancer Res. 2016; 22(18):4735-45.

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