Resting-state Brain Networks: Literature Review and Clinical Applications

Overview

Journal Neurol Sci

Specialty Neurology

Date 2011 Jun 14

PMID 21667095

Citations 212

Authors

Cristina Rosazza

Ludovico Minati

Affiliations

Soon will be listed here.

Abstract

This review focuses on resting-state functional connectivity, a functional MRI technique which allows the study of spontaneous brain activity generated under resting conditions. This approach is useful to explore the brain's functional organization and to examine if it is altered in neurological or psychiatric diseases. Resting-state functional connectivity has revealed a number of networks which are consistently found in healthy subjects and represent specific patterns of synchronous activity. In this review, we examine the behavioral, physiological and neurological evidences relevant to this coherent brain activity and, in particular, to each network. The investigation of functional connectivity appears promising from a clinical perspective, considering the amount of evidence regarding the importance of spontaneous activity and that resting-state paradigms are inherently simple to implement. We also discuss some examples of existing clinical applications, such as in Alzheimer's disease, and emerging possibilities such as in pre-operative mapping and disorders of consciousness.

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References

Damoiseaux J, Greicius M . Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity. Brain Struct Funct. 2009; 213(6):525-33. DOI: 10.1007/s00429-009-0208-6. View

Zhang D, Raichle M . Disease and the brain's dark energy. Nat Rev Neurol. 2010; 6(1):15-28. DOI: 10.1038/nrneurol.2009.198. View

Raichle M, MacLeod A, Snyder A, Powers W, Gusnard D, Shulman G . A default mode of brain function. Proc Natl Acad Sci U S A. 2001; 98(2):676-82. PMC: 14647. DOI: 10.1073/pnas.98.2.676. View

Esposito F, Aragri A, Latorre V, Popolizio T, Scarabino T, Cirillo S . Does the default-mode functional connectivity of the brain correlate with working-memory performances?. Arch Ital Biol. 2009; 147(1-2):11-20. View

Supekar K, Menon V, Rubin D, Musen M, Greicius M . Network analysis of intrinsic functional brain connectivity in Alzheimer's disease. PLoS Comput Biol. 2008; 4(6):e1000100. PMC: 2435273. DOI: 10.1371/journal.pcbi.1000100. View

Owen A, Coleman M, Boly M, Davis M, Laureys S, Pickard J . Detecting awareness in the vegetative state. Science. 2006; 313(5792):1402. DOI: 10.1126/science.1130197. View

Giacino J . The vegetative and minimally conscious states: consensus-based criteria for establishing diagnosis and prognosis. NeuroRehabilitation. 2005; 19(4):293-8. View

Cauda F, Micon B, Sacco K, Duca S, DAgata F, Geminiani G . Disrupted intrinsic functional connectivity in the vegetative state. J Neurol Neurosurg Psychiatry. 2009; 80(4):429-31. DOI: 10.1136/jnnp.2007.142349. View

Allen G, Barnard H, McColl R, Hester A, Fields J, Weiner M . Reduced hippocampal functional connectivity in Alzheimer disease. Arch Neurol. 2007; 64(10):1482-7. DOI: 10.1001/archneur.64.10.1482. View

10.

Minati L, Edginton T, Bruzzone M, Giaccone G . Current concepts in Alzheimer's disease: a multidisciplinary review. Am J Alzheimers Dis Other Demen. 2009; 24(2):95-121. PMC: 10846154. DOI: 10.1177/1533317508328602. View

11.

Long X, Zuo X, Kiviniemi V, Yang Y, Zou Q, Zhu C . Default mode network as revealed with multiple methods for resting-state functional MRI analysis. J Neurosci Methods. 2008; 171(2):349-55. DOI: 10.1016/j.jneumeth.2008.03.021. View

12.

Liu H, Buckner R, Talukdar T, Tanaka N, Madsen J, Stufflebeam S . Task-free presurgical mapping using functional magnetic resonance imaging intrinsic activity. J Neurosurg. 2009; 111(4):746-54. PMC: 3686552. DOI: 10.3171/2008.10.JNS08846. View

13.

Raichle M . Two views of brain function. Trends Cogn Sci. 2010; 14(4):180-90. DOI: 10.1016/j.tics.2010.01.008. View

14.

Laureys S . The neural correlate of (un)awareness: lessons from the vegetative state. Trends Cogn Sci. 2005; 9(12):556-9. DOI: 10.1016/j.tics.2005.10.010. View

15.

Roy A, Shehzad Z, Margulies D, Kelly A, Uddin L, Gotimer K . Functional connectivity of the human amygdala using resting state fMRI. Neuroimage. 2008; 45(2):614-26. PMC: 2735022. DOI: 10.1016/j.neuroimage.2008.11.030. View

16.

Himberg J, Hyvarinen A, Esposito F . Validating the independent components of neuroimaging time series via clustering and visualization. Neuroimage. 2004; 22(3):1214-22. DOI: 10.1016/j.neuroimage.2004.03.027. View

17.

Noirhomme Q, Soddu A, Lehembre R, Vanhaudenhuyse A, Boveroux P, Boly M . Brain connectivity in pathological and pharmacological coma. Front Syst Neurosci. 2010; 4:160. PMC: 3010745. DOI: 10.3389/fnsys.2010.00160. View

18.

van den Heuvel M, Mandl R, Hulshoff Pol H . Normalized cut group clustering of resting-state FMRI data. PLoS One. 2008; 3(4):e2001. PMC: 2291558. DOI: 10.1371/journal.pone.0002001. View

19.

Shulman G, Fiez J, Corbetta M, Buckner R, Miezin F, Raichle M . Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex. J Cogn Neurosci. 2013; 9(5):648-63. DOI: 10.1162/jocn.1997.9.5.648. View

20.

Cordes D, Haughton V, Arfanakis K, Carew J, Turski P, Moritz C . Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data. AJNR Am J Neuroradiol. 2001; 22(7):1326-33. PMC: 7975218. View