The Complexity of Vascular and Non-Vascular Complications of Diabetes: The Hong Kong Diabetes Registry

Overview

Journal Curr Cardiovasc Risk Rep

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2011 Jun 10

PMID 21654912

Citations 30

Authors

Juliana C N Chan

Wingyee So

Ronald C W Ma

Peter C Y Tong

Rebecca Wong

Xilin Yang

Affiliations

Soon will be listed here.

Abstract

Diabetes is a complex disease characterized by chronic hyperglycemia and multiple phenotypes. In 1995, we used a doctor-nurse-clerk team and structured protocol to establish the Hong Kong Diabetes Registry in a quality improvement program. By 2009, we had accrued 2616 clinical events in 9588 Chinese type 2 diabetic patients with a follow-up duration of 6 years. The detailed phenotypes at enrollment and follow-up medications have allowed us to develop a series of risk equations to predict multiple endpoints with high sensitivity and specificity. In this prospective database, we were able to validate findings from clinical trials in real practice, confirm close links between cardiovascular and renal disease, and demonstrate the emerging importance of cancer as a leading cause of death. In addition to serving as a tool for risk stratification and quality assurance, ongoing data analysis of the registry also reveals secular changes in disease patterns and identifies unmet needs.

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References

Ko G, So W, Tong P, Le Coguiec F, Kerr D, Lyubomirsky G . From design to implementation--the Joint Asia Diabetes Evaluation (JADE) program: a descriptive report of an electronic web-based diabetes management program. BMC Med Inform Decis Mak. 2010; 10:26. PMC: 2876072. DOI: 10.1186/1472-6947-10-26. View

Seshasai S, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N . Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011; 364(9):829-841. PMC: 4109980. DOI: 10.1056/NEJMoa1008862. View

Wong C, Ho A, Tong P, Yeung C, Chan J, Kong A . Aberrant expression of soluble co-stimulatory molecules and adhesion molecules in type 2 diabetic patients with nephropathy. J Clin Immunol. 2007; 28(1):36-43. DOI: 10.1007/s10875-007-9137-4. View

Luk A, So W, Ma R, Kong A, Ozaki R, Ng V . Metabolic syndrome predicts new onset of chronic kidney disease in 5,829 patients with type 2 diabetes: a 5-year prospective analysis of the Hong Kong Diabetes Registry. Diabetes Care. 2008; 31(12):2357-61. PMC: 2584195. DOI: 10.2337/dc08-0971. View

Hernandez-Diaz S, Adami H . Diabetes therapy and cancer risk: causal effects and other plausible explanations. Diabetologia. 2010; 53(5):802-8. DOI: 10.1007/s00125-010-1675-2. View

Tu S, Chang S, Chen J, Tien K, Hsiao J, Chen H . Prevention of diabetic nephropathy by tight target control in an asian population with type 2 diabetes mellitus: a 4-year prospective analysis. Arch Intern Med. 2010; 170(2):155-61. DOI: 10.1001/archinternmed.2009.471. View

Ma R, So W, Yang X, Yu L, Kong A, Ko G . Erectile dysfunction predicts coronary heart disease in type 2 diabetes. J Am Coll Cardiol. 2008; 51(21):2045-50. DOI: 10.1016/j.jacc.2008.02.051. View

Cheng A, Kong A, Wong V, So W, Chan H, Ho C . Chronic hepatitis B viral infection independently predicts renal outcome in type 2 diabetic patients. Diabetologia. 2006; 49(8):1777-84. DOI: 10.1007/s00125-006-0294-4. View

Chan J, Gagliardino J, Baik S, Chantelot J, Ferreira S, Hancu N . Multifaceted determinants for achieving glycemic control: the International Diabetes Management Practice Study (IDMPS). Diabetes Care. 2008; 32(2):227-33. PMC: 2628684. DOI: 10.2337/dc08-0435. View

10.

Piwernetz K, Home P, Snorgaard O, Antsiferov M, Krans M . Monitoring the targets of the St Vincent Declaration and the implementation of quality management in diabetes care: the DIABCARE initiative. The DIABCARE Monitoring Group of the St Vincent Declaration Steering Committee. Diabet Med. 1993; 10(4):371-7. DOI: 10.1111/j.1464-5491.1993.tb00083.x. View

11.

Leung W, So W, Tong P, Chan N, Chan J . Effects of structured care by a pharmacist-diabetes specialist team in patients with type 2 diabetic nephropathy. Am J Med. 2005; 118(12):1414. DOI: 10.1016/j.amjmed.2005.07.050. View

12.

Song X, Lee S, Ma R, So W, Cai J, Tam C . Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. Diabetologia. 2009; 52(8):1543-53. DOI: 10.1007/s00125-009-1400-1. View

13.

Parving H, Gall M, Skott P, Jorgensen H, Lokkegaard H, Jorgensen F . Prevalence and causes of albuminuria in non-insulin-dependent diabetic patients. Kidney Int. 1992; 41(4):758-62. DOI: 10.1038/ki.1992.118. View

14.

Kong A, Yang X, Ko G, So W, Chan W, Ma R . Effects of treatment targets on subsequent cardiovascular events in Chinese patients with type 2 diabetes. Diabetes Care. 2007; 30(4):953-9. DOI: 10.2337/dc06-2443. View

15.

Ma R, Tam C, Wang Y, Luk A, Hu C, Yang X . Genetic variants of the protein kinase C-beta 1 gene and development of end-stage renal disease in patients with type 2 diabetes. JAMA. 2010; 304(8):881-9. DOI: 10.1001/jama.2010.1191. View

16.

Warburg O . On the origin of cancer cells. Science. 1956; 123(3191):309-14. DOI: 10.1126/science.123.3191.309. View

17.

Yang X, So W, Tong P, Ma R, Kong A, Lam C . Development and validation of an all-cause mortality risk score in type 2 diabetes. Arch Intern Med. 2008; 168(5):451-7. DOI: 10.1001/archinte.168.5.451. View

18.

So W, Wang Y, Ng M, Yang X, Ma R, Lam V . Aldose reductase genotypes and cardiorenal complications: an 8-year prospective analysis of 1,074 type 2 diabetic patients. Diabetes Care. 2008; 31(11):2148-53. PMC: 2571065. DOI: 10.2337/dc08-0712. View

19.

Johnson J, Bowker S . Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials. Diabetologia. 2010; 54(1):25-31. DOI: 10.1007/s00125-010-1933-3. View

20.

Yang X, So W, Kong A, Clarke P, Ho C, Lam C . End-stage renal disease risk equations for Hong Kong Chinese patients with type 2 diabetes: Hong Kong Diabetes Registry. Diabetologia. 2006; 49(10):2299-308. DOI: 10.1007/s00125-006-0376-3. View