Different Types of Oscillations in Notch and Fgf Signaling Regulate the Spatiotemporal Periodicity of Somitogenesis

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2011 Jun 3

PMID 21632822

Citations 52

Authors

Yasutaka Niwa

Hiromi Shimojo

Akihiro Isomura

Aitor Gonzalez

Hitoshi Miyachi

Ryoichiro Kageyama

Affiliations

Soon will be listed here.

Abstract

Somitogenesis is controlled by cyclic genes such as Notch effectors and by the wave front established by morphogens such as Fgf8, but the precise mechanism of how these factors are coordinated remains to be determined. Here, we show that effectors of Notch and Fgf pathways oscillate in different dynamics and that oscillations in Notch signaling generate alternating phase shift, thereby periodically segregating a group of synchronized cells, whereas oscillations in Fgf signaling released these synchronized cells for somitogenesis at the same time. These results suggest that Notch oscillators define the prospective somite region, while Fgf oscillators regulate the pace of segmentation.

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