Evidence That NMDA Receptors Contribute to Synaptic Function in the Guinea Pig Medial Vestibular Nucleus

Overview

Journal Brain Res

Specialty Neurology

Date 1990 Apr 9

PMID 2161695

Citations 7

Authors

P F Smith

C L Darlington

J I HUBBARD

Affiliations

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Abstract

Single medial vestibular nucleus neurons were recorded from guinea pig brainstem slices in vitro while superfusing with the selective N-methyl-D-aspartate (NMDA) antagonists, MK801 and CPP. The majority of neurons tested showed a decrease in firing rate in response to these NMDA antagonists, suggesting that NMDA receptors may contribute to the resting activity of MVN neurons.

Citing Articles

Synaptic plasticity in medial vestibular nucleus neurons: comparison with computational requirements of VOR adaptation.

Menzies J, Porrill J, Dutia M, Dean P PLoS One. 2010; 5(10).

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Medial vestibular neurons are endogenous pacemakers whose discharge is modulated by neurotransmitters.

Lin Y, Carpenter D Cell Mol Neurobiol. 1993; 13(6):601-13.

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Ionic conductances contributing to spike repolarization and after-potentials in rat medial vestibular nucleus neurones.

Johnston A, MacLeod N, Dutia M J Physiol. 1994; 481 ( Pt 1):61-77.

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Guinea pig medial vestibular nucleus neurons in vitro respond to ACTH4-10 at picomolar concentrations.

Darlington C, Smith P, HUBBARD J Exp Brain Res. 1990; 82(3):637-40.

PMID: 1963409 DOI: 10.1007/BF00228805.

Excitatory amino acid receptors in normal and abnormal vestibular function.

Smith P, Waele C, Vidal P, Darlington C Mol Neurobiol. 1991; 5(2-4):369-87.

PMID: 1668393 DOI: 10.1007/BF02935559.