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NMDA Receptor-mediated Long Term Modulation of Electrically Evoked Field Potentials in the Rat Medial Vestibular Nuclei

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Journal Exp Brain Res
Specialty Neurology
Date 1992 Jan 1
PMID 1358669
Citations 10
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Abstract

The effect of high frequency stimulation (HFS) of the primary vestibular afferents on field potentials recorded in the ipsilateral Medial Vestibular Nuclei (MVN) was studied. Our results show that potentiation and depression can be induced in different portions of MVN, which are distinguishable by their anatomical organization. HFS induces potentiation of the monosynaptic component in the ventral portion of the MVN, whereas it provokes depression of the polysynaptic component in the dorsal portion of the same nucleus. The induction of both potentiation and depression was blocked under AP5 perfusion, thus demonstrating that NMDA receptor activation mediates both phenomena. Furthermore, the finding that the field potentials were not modified during perfusion with DL-AP5, as previously reported, supports the hypothesis that NMDA receptors are not involved in the normal synaptic transmission from the primary vestibular afferent fibres, but are only activated following hyperstimulation of this afferent system. Our results suggest that the mechanisms of long term modification of synaptic efficacy observed in MVN may underlie the plasticity phenomena occurring in vestibular nuclei.

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References
1.
Kimura F, Nishigori A, Shirokawa T, Tsumoto T . Long-term potentiation and N-methyl-D-aspartate receptors in the visual cortex of young rats. J Physiol. 1989; 414:125-44. PMC: 1189134. DOI: 10.1113/jphysiol.1989.sp017680. View

2.
Collingridge G, Kehl S, McLennan H . Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol. 1983; 334:33-46. PMC: 1197298. DOI: 10.1113/jphysiol.1983.sp014478. View

3.
Dememes D, Raymond J, Sans A . Selective retrograde labeling of neurons of the cat vestibular ganglion with [3H]D-aspartate. Brain Res. 1984; 304(1):188-91. DOI: 10.1016/0006-8993(84)90880-1. View

4.
Voogd J, Epema A, Rubertone J . Cerebello-vestibular connections of the anterior vermis. A retrograde tracer study in different mammals including primates. Arch Ital Biol. 1991; 129(1):3-19. View

5.
Smith P, Darlington C, HUBBARD J . Evidence that NMDA receptors contribute to synaptic function in the guinea pig medial vestibular nucleus. Brain Res. 1990; 513(1):149-51. DOI: 10.1016/0006-8993(90)91101-l. View