Mitochondrial Stress: a Bridge Between Mitochondrial Dysfunction and Metabolic Diseases?

Overview

Journal Cell Signal

Date 2011 May 28

PMID 21616143

Citations 57

Authors

Fang Hu

Feng Liu

Affiliations

Soon will be listed here.

Abstract

Under pathophysiological conditions such as obesity, excessive oxidation of nutrients may induce mitochondrial stress, leading to mitochondrial unfolded protein response (UPR(mt)) and initiation of a retrograde stress signaling pathway. Defects in the UPR(mt) and the retrograde signaling pathways may disrupt the integrity and homeostasis of the mitochondria, resulting in endoplasmic reticulum stress and insulin resistance. Improving the capacity of mitochondria to reduce stress may be an effective approach to improve mitochondria function and to suppress obesity-induced metabolic disorders such as insulin resistance and type 2 diabetes.

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References

Malhotra J, Kaufman R . The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol. 2007; 18(6):716-31. PMC: 2706143. DOI: 10.1016/j.semcdb.2007.09.003. View

Frisard M, Ravussin E . Energy metabolism and oxidative stress: impact on the metabolic syndrome and the aging process. Endocrine. 2006; 29(1):27-32. DOI: 10.1385/ENDO:29:1:27. View

Flynn J, Neher S, Kim Y, Sauer R, Baker T . Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals. Mol Cell. 2003; 11(3):671-83. DOI: 10.1016/s1097-2765(03)00060-1. View

Neupert W, Herrmann J . Translocation of proteins into mitochondria. Annu Rev Biochem. 2007; 76:723-49. DOI: 10.1146/annurev.biochem.76.052705.163409. View

Hori O, Ichinoda F, Tamatani T, Yamaguchi A, Sato N, Ozawa K . Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease. J Cell Biol. 2002; 157(7):1151-60. PMC: 2173558. DOI: 10.1083/jcb.200108103. View

Lindholm E, Klannemark M, Agardh E, Groop L, Agardh C . Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy. J Diabetes Complications. 2004; 18(2):103-7. DOI: 10.1016/S1056-8727(03)00019-9. View

Hamilton M, Hamilton D, Zderic T . Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes. 2007; 56(11):2655-67. DOI: 10.2337/db07-0882. View

Martins de Brito O, Scorrano L . Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature. 2008; 456(7222):605-10. DOI: 10.1038/nature07534. View

Puthalakath H, OReilly L, Gunn P, Lee L, Kelly P, Huntington N . ER stress triggers apoptosis by activating BH3-only protein Bim. Cell. 2007; 129(7):1337-49. DOI: 10.1016/j.cell.2007.04.027. View

10.

Bukau B, Horwich A . The Hsp70 and Hsp60 chaperone machines. Cell. 1998; 92(3):351-66. DOI: 10.1016/s0092-8674(00)80928-9. View

11.

Ngo J, Davies K . Importance of the lon protease in mitochondrial maintenance and the significance of declining lon in aging. Ann N Y Acad Sci. 2007; 1119:78-87. DOI: 10.1196/annals.1404.015. View

12.

Chatenay-Lapointe M, Shadel G . Stressed-out mitochondria get MAD. Cell Metab. 2010; 12(6):559-60. PMC: 3018381. DOI: 10.1016/j.cmet.2010.11.018. View

13.

Kelley D, He J, Menshikova E, Ritov V . Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes. 2002; 51(10):2944-50. DOI: 10.2337/diabetes.51.10.2944. View

14.

Li C, Cheng Y, Liao P, Yang Y, Kang J . Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 2010; 116(1):140-50. PMC: 2886854. DOI: 10.1093/toxsci/kfq085. View

15.

Kirstein-Miles J, Morimoto R . Peptides signal mitochondrial stress. Cell Metab. 2010; 11(3):177-8. DOI: 10.1016/j.cmet.2010.02.011. View

16.

Reddy R, Mao C, Baumeister P, Austin R, Kaufman R, Lee A . Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem. 2003; 278(23):20915-24. DOI: 10.1074/jbc.M212328200. View

17.

Strasser A, OConnor L, Dixit V . Apoptosis signaling. Annu Rev Biochem. 2000; 69:217-45. DOI: 10.1146/annurev.biochem.69.1.217. View

18.

Pinton P, Giorgi C, Siviero R, Zecchini E, Rizzuto R . Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene. 2008; 27(50):6407-18. PMC: 2844952. DOI: 10.1038/onc.2008.308. View

19.

Beller M, Thiel K, Thul P, Jackle H . Lipid droplets: a dynamic organelle moves into focus. FEBS Lett. 2010; 584(11):2176-82. DOI: 10.1016/j.febslet.2010.03.022. View

20.

Hartl F, Hayer-Hartl M . Molecular chaperones in the cytosol: from nascent chain to folded protein. Science. 2002; 295(5561):1852-8. DOI: 10.1126/science.1068408. View