Degrade, Move, Regroup: Signaling Control of Splicing Proteins

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 2011 May 21

PMID 21596569

Citations 52

Authors

Florian Heyd

Kristen W Lynch

Affiliations

Soon will be listed here.

Abstract

With recent advances in microarrays and sequencing it is now relatively straightforward to compare pre-mRNA splicing patterns in different cellular conditions on a genome-wide scale. Such studies have revealed extensive changes in cellular splicing programs in response to stimuli such as neuronal depolarization, DNA damage, immune signaling and cellular metabolic changes. However, for many years our understanding of the signaling pathways responsible for such splicing changes was greatly lacking. Excitingly, over the past few years this gap has begun to close. Recent studies now suggest notable trends in the mechanisms that link cellular stimuli to downstream alternative splicing events. These include regulated synthesis or degradation of splicing factors, differential protein-protein interactions, altered nuclear translocation and changes in transcription elongation.

Citing Articles

IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing.

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Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions.

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A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing.

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