In Vitro Assays Used to Measure the Activity of Topoisomerases

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1990 Jan 1

PMID 2158270

Citations 13

Authors

J F Barrett

J A Sutcliffe

T D Gootz

Affiliations

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Citing Articles

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The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine.

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Topoisomerase I inhibitors and drug resistance.

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Dual targeting of topoisomerase IV and gyrase to reduce mutant selection: direct testing of the paradigm by using WCK-1734, a new fluoroquinolone, and ciprofloxacin.

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References

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Hussy P, Maass G, Tummler B, Grosse F, Schomburg U . Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986; 29(6):1073-8. PMC: 180502. DOI: 10.1128/AAC.29.6.1073. View

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Sahai B, Kaplan J . A quantitative decatenation assay for type II topoisomerases. Anal Biochem. 1986; 156(2):364-79. DOI: 10.1016/0003-2697(86)90267-8. View

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Domagala J, Hanna L, Heifetz C, Hutt M, Mich T, Sanchez J . New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay. J Med Chem. 1986; 29(3):394-404. DOI: 10.1021/jm00153a015. View