Endosomal Trafficking of AMPA Receptors in Frontal Cortex of Elderly Patients with Schizophrenia

Overview

Journal Schizophr Res

Specialty Psychiatry

Date 2011 May 18

PMID 21576009

Citations 8

Authors

John C Hammond

Robert E McCullumsmith

Vahram Haroutunian

James H Meador-Woodruff

Affiliations

Soon will be listed here.

Abstract

Several lines of evidence indicate altered trafficking of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors in schizophrenia. Previous reports have implicated alterations in the endosomal trafficking of AMPA receptors in this illness. We hypothesized that late endosome content of AMPA receptor subunits is altered in schizophrenia. Accordingly, we developed a technique to isolate and measure contents of late endosomes from postmortem human tissue. We found no changes in the expression of the AMPA subunits, GluR1-4, in late endosomes from the dorsolateral prefrontal cortex in schizophrenia. We also hypothesized that proteins involved in the sorting and trafficking of AMPA receptors between endosomal compartments would be altered in schizophrenia. We found no changes in expression of multiple proteins associated with these processes (dynamin3, Arc/ARG3.1, NEEP21, GRASP1, liprin α, and syntaxin13). Together, these data suggest that endosomal trafficking of AMPA receptors in the prefrontal cortex may be largely intact in schizophrenia.

Citing Articles

Altered distribution and localization of organellar Na/H exchangers in postmortem schizophrenia dorsolateral prefrontal cortex.

Pruett B, Pinner A, Kim P, Meador-Woodruff J Transl Psychiatry. 2023; 13(1):34.

PMID: 36732328 PMC: 9895429. DOI: 10.1038/s41398-023-02336-2.

Molecular evidence of synaptic pathology in the CA1 region in schizophrenia.

Matosin N, Fernandez-Enright F, Lum J, Engel M, Andrews J, Gassen N NPJ Schizophr. 2016; 2:16022.

PMID: 27430010 PMC: 4944906. DOI: 10.1038/npjschz.2016.22.

Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.

MacDonald M, Ding Y, Newman J, Hemby S, Penzes P, Lewis D Biol Psychiatry. 2014; 77(11):959-68.

PMID: 25433904 PMC: 4428927. DOI: 10.1016/j.biopsych.2014.09.006.

Postmortem brain: an underutilized substrate for studying severe mental illness.

McCullumsmith R, Hammond J, Shan D, Meador-Woodruff J Neuropsychopharmacology. 2013; 39(1):65-87.

PMID: 24091486 PMC: 3857666. DOI: 10.1038/npp.2013.239.

N-linked glycosylation of cortical N-methyl-D-aspartate and kainate receptor subunits in schizophrenia.

Tucholski J, Simmons M, Pinner A, McMillan L, Haroutunian V, Meador-Woodruff J Neuroreport. 2013; 24(12):688-91.

PMID: 23820740 PMC: 3919653. DOI: 10.1097/WNR.0b013e328363bd8a.

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