Recycling Endosomes Supply AMPA Receptors for LTP

Overview

Journal Science

Specialty Science

Date 2004 Sep 28

PMID 15448273

Citations 389

Authors

Mikyoung Park

Esther C Penick

Jeffrey G Edwards

Julie A Kauer

Michael D Ehlers

Affiliations

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Abstract

Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors. However, the source of AMPA receptors mobilized during LTP is unknown. We report that AMPA receptors are transported from recycling endosomes to the plasma membrane for LTP. Stimuli that triggered LTP promoted not only AMPA receptor insertion but also generalized recycling of cargo and membrane from endocytic compartments. Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification.

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