Depletion and Recovery of Lymphoid Subsets Following Morphine Administration

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 2011 May 12

PMID 21557737

Citations 22

Authors

E Y Zhang

J Xiong

B L Parker

A Y Chen

P E Fields

X Ma

J Qiu

T M Yankee

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Opioid use and abuse has been linked to significant immunosuppression, which has been attributed, in part, to drug-induced depletion of lymphocytes. We sought to define the mechanisms by which lymphocyte populations are depleted and recover following morphine treatment in mice.

Experimental Approach: Mice were implanted with morphine pellets and B- and T-cell subsets in the bone marrow, thymus, spleen and lymph nodes were analysed at various time points. We also examined the effects of morphine on T-cell development using an ex vivo assay.

Key Results: The lymphocyte populations most susceptible to morphine-induced depletion were the precursor cells undergoing selection. As the lymphocytes recovered, more lymphocyte precursors proliferated than in control mice. In addition, peripheral T-cells displayed evidence that they had undergone homeostatic proliferation during the recovery phase of the experiments.

Conclusions And Implications: The recovery of lymphocytes following morphine-induced depletion occurred in the presence of morphine and via increased proliferation of lymphoid precursors and homeostatic proliferation of T-cells.

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