The Pro-apoptotic Protein Bim is a MicroRNA Target in Kidney Progenitors

Overview

Journal J Am Soc Nephrol

Specialty Nephrology

Date 2011 May 7

PMID 21546576

Citations 64

Authors

Jacqueline Ho

Priyanka Pandey

Tobias Schatton

Sunder Sims-Lucas

Myda Khalid

Markus H Frank

Sunny Hartwig

Jordan A Kreidberg

Affiliations

Soon will be listed here.

Abstract

Understanding the mechanisms that regulate nephron progenitors during kidney development should aid development of therapies for renal failure. MicroRNAs, which modulate gene expression through post-transcriptional repression of specific target mRNAs, contribute to the differentiation of stem cells, but their role in nephrogenesis is incompletely understood. Here, we found that the loss of miRNAs in nephron progenitors results in a premature depletion of this population during kidney development. Increased apoptosis and expression of the pro-apoptotic protein Bim accompanied this depletion. Profiling of miRNA expression during nephrogenesis identified several highly expressed miRNAs (miR-10a, miR-106b, miR-17-5p) in nephron progenitors that are either known or predicted to target Bim. We propose that modulation of apoptosis by miRNAs may determine congenital nephron endowment. Furthermore, our data implicate the pro-apoptotic protein Bim as a miRNA target in nephron progenitors.

Citing Articles

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