The Inflammasome in Atherosclerosis and Type 2 Diabetes

Overview

Journal Sci Transl Med

Specialties General Medicine
Science

Date 2011 May 6

PMID 21543720

Citations 79

Authors

Seth L Masters

Eicke Latz

Luke A J ONeill

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is the cause of morbiditiy for 70% of patients with type 2 diabetes. In both of these diseases, a protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are pathogenic inflammatory cytokines. Triggers for the inflammasome are obesity-related factors, such as cholesterol crystals in atherosclerosis, or hyperglycemia, ceramides, and islet amyloid polypeptide in type 2 diabetes. Therapeutics that target IL-1β in clinical trials for type 2 diabetes might also decrease the incidence of atherosclerosis.

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