The Role of Notch Signaling in Adult Neurogenesis

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2011 May 5

PMID 21541768

Citations 46

Authors

Itaru Imayoshi

Ryoichiro Kageyama

Affiliations

Soon will be listed here.

Abstract

Neurogenesis occurs throughout adulthood in the mammalian brain. Newly born neurons are incorporated into the functional networks of both the olfactory bulb and the hippocampal dentate gyrus, and there is growing evidence that adult neurogenesis is important for various brain functions. Continuous neurogenesis is achieved by the coordinated proliferation and differentiation of adult neural stem cells. In this review, we discuss the recent findings concerning the roles of Notch signaling in adult neural stem cells.

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