The Act of Controlling Adult Stem Cell Dynamics: Insights from Animal Models

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2021 May 5

PMID 33946143

Citations 6

Authors

Meera Krishnan

Sahil Kumar

Luis Johnson Kangale

Eric Ghigo

Prasad Abnave

Affiliations

Soon will be listed here.

Abstract

Adult stem cells (ASCs) are the undifferentiated cells that possess self-renewal and differentiation abilities. They are present in all major organ systems of the body and are uniquely reserved there during development for tissue maintenance during homeostasis, injury, and infection. They do so by promptly modulating the dynamics of proliferation, differentiation, survival, and migration. Any imbalance in these processes may result in regeneration failure or developing cancer. Hence, the dynamics of these various behaviors of ASCs need to always be precisely controlled. Several genetic and epigenetic factors have been demonstrated to be involved in tightly regulating the proliferation, differentiation, and self-renewal of ASCs. Understanding these mechanisms is of great importance, given the role of stem cells in regenerative medicine. Investigations on various animal models have played a significant part in enriching our knowledge and giving In Vivo in-sight into such ASCs regulatory mechanisms. In this review, we have discussed the recent In Vivo studies demonstrating the role of various genetic factors in regulating dynamics of different ASCs viz. intestinal stem cells (ISCs), neural stem cells (NSCs), hematopoietic stem cells (HSCs), and epidermal stem cells (Ep-SCs).

Citing Articles

Impact of G1 phase kinetics on the acquisition of stemness in cancer cells: the critical role of cyclin D.

Ahmadi Y, Faiq T, Abolhasani S Mol Biol Rep. 2025; 52(1):230.

PMID: 39951181 DOI: 10.1007/s11033-025-10351-3.

Unraveling the Mechanism of Impaired Osteogenic Differentiation in Osteoporosis: Insights from Gene Polymorphism.

Krasnova O, Sopova J, Kovaleva A, Semenova P, Zhuk A, Smirnova D Cells. 2025; 13(24.

PMID: 39768200 PMC: 11674950. DOI: 10.3390/cells13242110.

Starting Editorial of "Cellular Damage: Protection and Induction" Addressing Hot Topics in Cellular Damage, Protection of Cells and Therapy Targeting Bad Cells.

Tan S, Zhou W Int J Mol Sci. 2023; 24(18).

PMID: 37762004 PMC: 10531010. DOI: 10.3390/ijms241813702.

TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in .

Gong J, Nirala N, Chen J, Wang F, Gu P, Wen Q Sci Adv. 2023; 9(21):eadc9660.

PMID: 37224252 PMC: 10208578. DOI: 10.1126/sciadv.adc9660.

Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway.

Kim J, Yang Y, Hong J, Chaugule S, Chun H, van der Meulen M Elife. 2022; 11.

PMID: 35975983 PMC: 9417416. DOI: 10.7554/eLife.78069.

References

Samarut E, Bekri A, Drapeau P . Transcriptomic Analysis of Purified Embryonic Neural Stem Cells from Zebrafish Embryos Reveals Signaling Pathways Involved in Glycine-Dependent Neurogenesis. Front Mol Neurosci. 2016; 9:22. PMC: 4815022. DOI: 10.3389/fnmol.2016.00022. View

Shitasako S, Ito Y, Ito R, Ueda Y, Shimizu Y, Ohshima T . Wnt and Shh signals regulate neural stem cell proliferation and differentiation in the optic tectum of adult zebrafish. Dev Neurobiol. 2017; 77(10):1206-1220. DOI: 10.1002/dneu.22509. View

Jiang P, Zhu T, Xia Z, Gao F, Gu W, Chen X . Inhibition of MAPK/ERK signaling blocks hippocampal neurogenesis and impairs cognitive performance in prenatally infected neonatal rats. Eur Arch Psychiatry Clin Neurosci. 2015; 265(6):497-509. DOI: 10.1007/s00406-015-0588-y. View

Calvi L, Adams G, Weibrecht K, Weber J, Olson D, Knight M . Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003; 425(6960):841-6. DOI: 10.1038/nature02040. View

Batlle E, Henderson J, Beghtel H, van den Born M, Sancho E, Huls G . Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell. 2002; 111(2):251-63. DOI: 10.1016/s0092-8674(02)01015-2. View

Egger B, Gold K, Brand A . Notch regulates the switch from symmetric to asymmetric neural stem cell division in the Drosophila optic lobe. Development. 2010; 137(18):2981-7. PMC: 2926952. DOI: 10.1242/dev.051250. View

Jiang H, Tian A, Jiang J . Intestinal stem cell response to injury: lessons from Drosophila. Cell Mol Life Sci. 2016; 73(17):3337-49. PMC: 4998060. DOI: 10.1007/s00018-016-2235-9. View

Tasaki J, Shibata N, Nishimura O, Itomi K, Tabata Y, Son F . ERK signaling controls blastema cell differentiation during planarian regeneration. Development. 2011; 138(12):2417-27. DOI: 10.1242/dev.060764. View

Pedro M, Lund K, Iglesias-Bartolome R . The landscape of GPCR signaling in the regulation of epidermal stem cell fate and skin homeostasis. Stem Cells. 2020; . DOI: 10.1002/stem.3273. View

10.

Zhang Y, Zhou Z, Han W, Zhang L, Song W, Huang J . Oleanolic Acid Inhibiting the Differentiation of Neural Stem Cells into Astrocyte by Down-Regulating JAK/STAT Signaling Pathway. Am J Chin Med. 2016; 44(1):103-17. DOI: 10.1142/S0192415X16500075. View

11.

Kandyba E, Leung Y, Chen Y, Widelitz R, Chuong C, Kobielak K . Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Proc Natl Acad Sci U S A. 2013; 110(4):1351-6. PMC: 3557042. DOI: 10.1073/pnas.1121312110. View

12.

Zhou D, Zhang Y, Wu H, Barry E, Yin Y, Lawrence E . Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A. 2011; 108(49):E1312-20. PMC: 3241824. DOI: 10.1073/pnas.1110428108. View

13.

Tian H, Biehs B, Chiu C, Siebel C, Wu Y, Costa M . Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 2015; 11(1):33-42. PMC: 4394041. DOI: 10.1016/j.celrep.2015.03.007. View

14.

Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H . BMP restricts stemness of intestinal Lgr5 stem cells by directly suppressing their signature genes. Nat Commun. 2017; 8:13824. PMC: 5227110. DOI: 10.1038/ncomms13824. View

15.

Wei L, Ding Y, Liu Y, Duan L, Bai Y, Shi M . Low-dose radiation stimulates Wnt/β-catenin signaling, neural stem cell proliferation and neurogenesis of the mouse hippocampus in vitro and in vivo. Curr Alzheimer Res. 2012; 9(3):278-89. DOI: 10.2174/156720512800107627. View

16.

Liu N, Yin Y, Wang H, Zhou Z, Sheng X, Fu H . Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling. PLoS Genet. 2019; 15(9):e1008368. PMC: 6760834. DOI: 10.1371/journal.pgen.1008368. View

17.

Ahn S, Joyner A . In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature. 2005; 437(7060):894-7. DOI: 10.1038/nature03994. View

18.

Plikus M, Mayer J, de la Cruz D, Baker R, Maini P, Maxson R . Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature. 2008; 451(7176):340-4. PMC: 2696201. DOI: 10.1038/nature06457. View

19.

Vauclair S, Nicolas M, Barrandon Y, Radtke F . Notch1 is essential for postnatal hair follicle development and homeostasis. Dev Biol. 2005; 284(1):184-93. DOI: 10.1016/j.ydbio.2005.05.018. View

20.

Ding R, Weynans K, Bossing T, Barros C, Berger C . The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells. Nat Commun. 2016; 7:10510. PMC: 4740179. DOI: 10.1038/ncomms10510. View