Addicted to Myc--but Why?

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2011 May 4

PMID 21536730

Citations 7

Authors

Bjorn von Eyss

Martin Eilers

Affiliations

Soon will be listed here.

Abstract

Many tumors continuously depend on the initiating oncogenes, but whether this extends to their downstream targets is unclear. In this issue of Genes & Development, Sodir and colleagues (pp. 907-916) demonstrate an essential role for endogenous Myc proteins in maintaining the tumor microenvironment, providing an unexpected molecular explanation for addiction to Myc.

Citing Articles

MYC protein stability is negatively regulated by BRD4.

Devaiah B, Mu J, Akman B, Uppal S, Weissman J, Cheng D Proc Natl Acad Sci U S A. 2020; 117(24):13457-13467.

PMID: 32482868 PMC: 7306749. DOI: 10.1073/pnas.1919507117.

Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc.

Masso-Valles D, Soucek L Cells. 2020; 9(4).

PMID: 32260326 PMC: 7226798. DOI: 10.3390/cells9040883.

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy.

Beaulieu M, Jauset T, Masso-Valles D, Martinez-Martin S, Rahl P, Maltais L Sci Transl Med. 2019; 11(484).

PMID: 30894502 PMC: 6522349. DOI: 10.1126/scitranslmed.aar5012.

Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells.

Sengupta P, Banerjee N, Roychowdhury T, Dutta A, Chattopadhyay S, Chatterjee S Nucleic Acids Res. 2018; 46(19):9932-9950.

PMID: 30239898 PMC: 6212778. DOI: 10.1093/nar/gky824.

Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.

Jung K, Wang H, Teriete P, Yap J, Chen L, Lanning M J Med Chem. 2015; 58(7):3002-24.

PMID: 25734936 PMC: 4955407. DOI: 10.1021/jm501440q.

References

Soucek L, Whitfield J, Martins C, Finch A, Murphy D, Sodir N . Modelling Myc inhibition as a cancer therapy. Nature. 2008; 455(7213):679-83. PMC: 4485609. DOI: 10.1038/nature07260. View

Herkert B, Dwertmann A, Herold S, Abed M, Naud J, Finkernagel F . The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis. J Cell Biol. 2010; 188(6):905-18. PMC: 2845071. DOI: 10.1083/jcb.200908103. View

Hanahan D, Folkman J . Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996; 86(3):353-64. DOI: 10.1016/s0092-8674(00)80108-7. View

Sansom O, Meniel V, Muncan V, Phesse T, Wilkins J, Reed K . Myc deletion rescues Apc deficiency in the small intestine. Nature. 2007; 446(7136):676-9. DOI: 10.1038/nature05674. View

Gordan J, Thompson C, Simon M . HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell. 2007; 12(2):108-13. PMC: 3215289. DOI: 10.1016/j.ccr.2007.07.006. View

Baudino T, McKay C, Pendeville-Samain H, Nilsson J, Maclean K, White E . c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 2002; 16(19):2530-43. PMC: 187450. DOI: 10.1101/gad.1024602. View

Giuriato S, Ryeom S, Fan A, Bachireddy P, Lynch R, Rioth M . Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. Proc Natl Acad Sci U S A. 2006; 103(44):16266-71. PMC: 1637571. DOI: 10.1073/pnas.0608017103. View

Kress T, Cannell I, Brenkman A, Samans B, Gaestel M, Roepman P . The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. Mol Cell. 2011; 41(4):445-57. DOI: 10.1016/j.molcel.2011.01.023. View

Yustein J, Liu Y, Gao P, Jie C, Le A, Vuica-Ross M . Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci U S A. 2010; 107(8):3534-9. PMC: 2840500. DOI: 10.1073/pnas.0901230107. View

10.

Laurenti E, Varnum-Finney B, Wilson A, Ferrero I, Blanco-Bose W, Ehninger A . Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell. 2008; 3(6):611-24. PMC: 2635113. DOI: 10.1016/j.stem.2008.09.005. View

11.

Sodir N, Swigart L, Karnezis A, Hanahan D, Evan G, Soucek L . Endogenous Myc maintains the tumor microenvironment. Genes Dev. 2011; 25(9):907-16. PMC: 3084025. DOI: 10.1101/gad.2038411. View

12.

Soucek L, Jucker R, Panacchia L, Ricordy R, Tato F, Nasi S . Omomyc, a potential Myc dominant negative, enhances Myc-induced apoptosis. Cancer Res. 2002; 62(12):3507-10. View

13.

Rakhra K, Bachireddy P, Zabuawala T, Zeiser R, Xu L, Kopelman A . CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell. 2010; 18(5):485-98. PMC: 2991103. DOI: 10.1016/j.ccr.2010.10.002. View

14.

Boone D, Qi Y, Li Z, Hann S . Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. Proc Natl Acad Sci U S A. 2010; 108(2):632-7. PMC: 3021028. DOI: 10.1073/pnas.1008848108. View

15.

Weinstein I . Cancer. Addiction to oncogenes--the Achilles heal of cancer. Science. 2002; 297(5578):63-4. DOI: 10.1126/science.1073096. View

16.

Arvanitis C, Felsher D . Conditional transgenic models define how MYC initiates and maintains tumorigenesis. Semin Cancer Biol. 2006; 16(4):313-7. DOI: 10.1016/j.semcancer.2006.07.012. View

17.

Luo J, Solimini N, Elledge S . Principles of cancer therapy: oncogene and non-oncogene addiction. Cell. 2009; 136(5):823-37. PMC: 2894612. DOI: 10.1016/j.cell.2009.02.024. View

18.

Smith A, Verrecchia A, Faga G, Doni M, Perna D, Martinato F . A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition. Oncogene. 2008; 28(3):422-30. DOI: 10.1038/onc.2008.395. View

19.

Barna M, Pusic A, Zollo O, Costa M, Kondrashov N, Rego E . Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature. 2008; 456(7224):971-5. PMC: 2880952. DOI: 10.1038/nature07449. View

20.

Nilsson J, Keller U, Baudino T, Yang C, Norton S, Old J . Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. Cancer Cell. 2005; 7(5):433-44. DOI: 10.1016/j.ccr.2005.03.036. View