The Role of Obesity in Preeclampsia

Overview

Journal Pregnancy Hypertens

Publisher Elsevier

Date 2011 May 3

PMID 21532964

Citations 76

Authors

James M Roberts

Lisa M Bodnar

Thelma E Patrick

Robert W Powers

Affiliations

Soon will be listed here.

Abstract

The incidence of obesity is increasing at an alarming rate. There is compelling evidence that obesity increases the risk of preeclampsia about 3-fold, and in developed countries is the leading attributable risk for the disorder. In this presentation we explore this relationship and propose targets for future studies guided by the much more extensively studied relationship of obesity to cardiovascular disease. We further address the hypothesis that asymmetric dimethyl arginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be one convergence point for the mechanism by which obesity increases the risk of preeclampsia. We conclude with consideration of the clinical implications of this information.

Citing Articles

Epigenetic biomarker for preeclampsia-associated preterm birth and potential preventative medicine.

Nilsson E, Winchester P, Proctor C, Beck D, Skinner M Environ Epigenet. 2024; 10(1):dvae022.

PMID: 39606093 PMC: 11602036. DOI: 10.1093/eep/dvae022.

Effectiveness of first trimester maternal fat tissue measurement in prediction of gestational diabetes: a prospective cohort study.

Emeklioglu C, Acar Sirinoglu H, Ozalp M, Eren M, Akkoc Demirel E, Genc S J Turk Ger Gynecol Assoc. 2024; 25(4):224-230.

PMID: 39254292 PMC: 11632638. DOI: 10.4274/jtgga.galenos.2023.2023-4-6.

The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis.

Wang Y, Ssengonzi R, Townley-Tilson W, Kayashima Y, Maeda-Smithies N, Li F Int J Mol Sci. 2024; 25(16).

PMID: 39201703 PMC: 11354233. DOI: 10.3390/ijms25169017.

Different Lengths of Gestational Exposure to Secondhand Smoke or e-Cigarette Vapor Induce the Development of Placental Disease Symptoms.

Kirkham M, Cooper C, Broberg E, Robertson P, Clarke D, Pickett B Cells. 2024; 13(12.

PMID: 38920640 PMC: 11201565. DOI: 10.3390/cells13121009.

Endothelial Nitric Oxide synthase (eNOS) in Preeclampsia: An Update.

Ssengonzi R, Wang Y, Maeda-Smithies N, Li F J Pregnancy Child Health. 2024; 6.

PMID: 38476467 PMC: 10929736. DOI: 10.29011/jpch-121.100021.

References

McLaughlin T, Stuhlinger M, Lamendola C, Abbasi F, Bialek J, Reaven G . Plasma asymmetric dimethylarginine concentrations are elevated in obese insulin-resistant women and fall with weight loss. J Clin Endocrinol Metab. 2006; 91(5):1896-900. DOI: 10.1210/jc.2005-1441. View

Founds S, Powers R, Patrick T, Ren D, Harger G, Markovic N . A comparison of circulating TNF-alpha in obese and lean women with and without preeclampsia. Hypertens Pregnancy. 2008; 27(1):39-48. PMC: 2675917. DOI: 10.1080/10641950701825838. View

Tran C, Leiper J, Vallance P . The DDAH/ADMA/NOS pathway. Atheroscler Suppl. 2003; 4(4):33-40. DOI: 10.1016/s1567-5688(03)00032-1. View

Lu D, Yang X, Wu Y, Wang H, Huang H, Dong M . Serum adiponectin, leptin and soluble leptin receptor in pre-eclampsia. Int J Gynaecol Obstet. 2006; 95(2):121-6. DOI: 10.1016/j.ijgo.2006.06.015. View

Achan V, Broadhead M, Malaki M, Whitley G, Leiper J, MacAllister R . Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol. 2003; 23(8):1455-9. DOI: 10.1161/01.ATV.0000081742.92006.59. View

Berg A, Scherer P . Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005; 96(9):939-49. DOI: 10.1161/01.RES.0000163635.62927.34. View

Eid H, Arnesen H, Hjerkinn E, Lyberg T, Seljeflot I . Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine. Metabolism. 2004; 53(12):1574-9. DOI: 10.1016/j.metabol.2004.06.026. View

Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K . Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med. 2003; 9(11):1370-6. DOI: 10.1038/nm948. View

Millatt L, Whitley G, Li D, Leiper J, Siragy H, Carey R . Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension. Circulation. 2003; 108(12):1493-8. DOI: 10.1161/01.CIR.0000089087.25930.FF. View

10.

Ukkola O, Bouchard C . Clustering of metabolic abnormalities in obese individuals: the role of genetic factors. Ann Med. 2001; 33(2):79-90. DOI: 10.3109/07853890109002062. View

11.

Teppa R, Ness R, Crombleholme W, Roberts J . Free leptin is increased in normal pregnancy and further increased in preeclampsia. Metabolism. 2000; 49(8):1043-8. DOI: 10.1053/meta.2000.7707. View

12.

van der Vleuten G, Veerkamp M, van Tits L, Toenhake H, den Heijer M, Stalenhoef A . Elevated leptin levels in subjects with familial combined hyperlipidemia are associated with the increased risk for CVD. Atherosclerosis. 2005; 183(2):355-60. DOI: 10.1016/j.atherosclerosis.2005.03.019. View

13.

Roberts J, Gammill H . Preeclampsia: recent insights. Hypertension. 2005; 46(6):1243-9. DOI: 10.1161/01.HYP.0000188408.49896.c5. View

14.

Title L, Cummings P, Giddens K, Genest Jr J, Nassar B . Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. J Am Coll Cardiol. 2000; 36(3):758-65. DOI: 10.1016/s0735-1097(00)00809-3. View

15.

Rytlewski K, Olszanecki R, Korbut R, Zdebski Z . Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur J Clin Invest. 2005; 35(1):32-7. DOI: 10.1111/j.1365-2362.2005.01445.x. View

16.

Yoo J, Lee S . Elevated levels of plasma homocyst(e)ine and asymmetric dimethylarginine in elderly patients with stroke. Atherosclerosis. 2001; 158(2):425-30. DOI: 10.1016/s0021-9150(01)00444-0. View

17.

Bodnar L, Ness R, Markovic N, Roberts J . The risk of preeclampsia rises with increasing prepregnancy body mass index. Ann Epidemiol. 2005; 15(7):475-82. DOI: 10.1016/j.annepidem.2004.12.008. View

18.

Minocci A, Savia G, Lucantoni R, Berselli M, Tagliaferri M, Calo G . Leptin plasma concentrations are dependent on body fat distribution in obese patients. Int J Obes Relat Metab Disord. 2000; 24(9):1139-44. DOI: 10.1038/sj.ijo.0801385. View

19.

Irgens H, Reisaeter L, Irgens L, Lie R . Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. BMJ. 2001; 323(7323):1213-7. PMC: 59993. DOI: 10.1136/bmj.323.7323.1213. View

20.

Staff A, Berge L, Haugen G, Lorentzen B, Mikkelsen B, Henriksen T . Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand. 2003; 83(1):103-7. View