A Comparison of Circulating TNF-alpha in Obese and Lean Women with and Without Preeclampsia

Overview

Journal Hypertens Pregnancy

Publisher Informa Healthcare

Date 2008 Feb 23

PMID 18293203

Citations 14

Authors

Sandra A Founds

Robert W Powers

Thelma E Patrick

Dianxu Ren

Gail F Harger

Nina Markovic

James M Roberts

Affiliations

Soon will be listed here.

Abstract

Objectives: We hypothesized that TNF-alpha would be higher in obese versus lean women with preeclampsia.

Methods: Total plasma TNF-alpha was measured in a nested case-control study of 123 nulliparous lean and obese control women and women with preeclampsia.

Results: Adjusted mean TNF-alpha concentrations were 0.97 +/- 0.11 (pg/mL +/- SEM) in lean controls, 1.01 +/- 0.10 in obese controls, 1.43 +/- 0.11 in lean women with preeclampsia and 1.16 +/- 0.11 in obese women with preeclampsia. Pregnancy outcome was the single predictor of TNF-alpha concentration in the general linear regression model (p = 0.04).

Conclusion: TNF-alpha concentration was higher in preeclampsia compared with control subjects. Obesity was not associated with higher TNF-alpha concentrations in either preeclampsia or control subjects.

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References

Tsigos C, Kyrou I, Chala E, Tsapogas P, Stavridis J, Raptis S . Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity. Metabolism. 1999; 48(10):1332-5. DOI: 10.1016/s0026-0495(99)90277-9. View

Bartha J, Romero-Carmona R, Comino-Delgado R . The relationships between leptin and inflammatory cytokines in women with pre-eclampsia. BJOG. 2002; 108(12):1272-6. DOI: 10.1111/j.1471-0528.2001.00284.x. View

. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000; 183(1):S1-S22. View

Hayashi M, Ueda Y, Yamaguchi T, Sohma R, Shibazaki M, Ohkura T . Tumor necrosis factor-alpha in the placenta is not elevated in pre-eclamptic patients despite its elevation in peripheral blood. Am J Reprod Immunol. 2005; 53(3):113-9. DOI: 10.1111/j.1600-0897.2005.00253.x. View

Evans R, Powers R, Ness R, Cropcho L, Daftary A, Harger G . Maternal and fetal amino acid concentrations and fetal outcomes during pre-eclampsia. Reproduction. 2003; 125(6):785-90. DOI: 10.1530/rep.0.1250785. View

Hamai Y, Fujii T, Yamashita T, Nishina H, Kozuma S, Mikami Y . Evidence for an elevation in serum interleukin-2 and tumor necrosis factor-alpha levels before the clinical manifestations of preeclampsia. Am J Reprod Immunol. 1997; 38(2):89-93. DOI: 10.1111/j.1600-0897.1997.tb00281.x. View

Luppi P . How immune mechanisms are affected by pregnancy. Vaccine. 2003; 21(24):3352-7. DOI: 10.1016/s0264-410x(03)00331-1. View

Freeman D, McManus F, Brown E, Cherry L, Norrie J, Ramsay J . Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension. 2004; 44(5):708-14. DOI: 10.1161/01.HYP.0000143849.67254.ca. View

Hauner H . The new concept of adipose tissue function. Physiol Behav. 2004; 83(4):653-8. DOI: 10.1016/j.physbeh.2004.09.016. View

10.

Kaaja R, Poyhonen-Alho M . Insulin resistance and sympathetic overactivity in women. J Hypertens. 2005; 24(1):131-41. DOI: 10.1097/01.hjh.0000194121.19851.e5. View

11.

Dong M, He J, Wang Z, Xie X, Wang H . Placental imbalance of Th1- and Th2-type cytokines in preeclampsia. Acta Obstet Gynecol Scand. 2005; 84(8):788-93. DOI: 10.1111/j.0001-6349.2005.00714.x. View

12.

Visser W, Beckmann I, Knook M, Wallenburg H . Soluble tumor necrosis factor receptor II and soluble cell adhesion molecule 1 as markers of tumor necrosis factor-alpha release in preeclampsia. Acta Obstet Gynecol Scand. 2002; 81(8):713-9. View

13.

Schipper E, Bolte A, Schalkwijk C, Van Geijn H, Dekker G . TNF-receptor levels in preeclampsia--results of a longitudinal study in high-risk women. J Matern Fetal Neonatal Med. 2006; 18(5):283-7. DOI: 10.1080/14767050500246466. View

14.

Lewis G . Beyond the numbers: reviewing maternal deaths and complications to make pregnancy safer. Br Med Bull. 2004; 67:27-37. DOI: 10.1093/bmb/ldg009. View

15.

Sacks G, Sargent I, Redman C . An innate view of human pregnancy. Immunol Today. 1999; 20(3):114-8. DOI: 10.1016/s0167-5699(98)01393-0. View

16.

Conrad K, Benyo D . Placental cytokines and the pathogenesis of preeclampsia. Am J Reprod Immunol. 1997; 37(3):240-9. DOI: 10.1111/j.1600-0897.1997.tb00222.x. View

17.

Conrad K, Miles T, Benyo D . Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol. 1998; 40(2):102-11. DOI: 10.1111/j.1600-0897.1998.tb00398.x. View

18.

Kobayashi K . Adipokines: therapeutic targets for metabolic syndrome. Curr Drug Targets. 2005; 6(4):525-9. DOI: 10.2174/1389450054021972. View

19.

Dekker G, Sibai B . Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol. 1998; 179(5):1359-75. DOI: 10.1016/s0002-9378(98)70160-7. View

20.

Trayhurn P, Wood I . Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 2004; 92(3):347-55. DOI: 10.1079/bjn20041213. View