KLF13 Sustains Thymic Memory-like CD8(+) T Cells in BALB/c Mice by Regulating IL-4-generating Invariant Natural Killer T Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2011 Apr 13

PMID 21482696

Citations 54

Authors

Dazhi Lai

Jinfang Zhu

Tianhong Wang

Jane Hu-Li

Masaki Terabe

Jay A Berzofsky

Carol Clayberger

Alan M Krensky

Affiliations

Soon will be listed here.

Abstract

"Memory-like T cells" are a subset of thymic cells that acquire effector function through the maturation process rather than interaction with specific antigen. Disruption of genes encoding T cell signaling proteins or transcription factors have provided insights into the differentiation of such cells. In this study, we show that in BALB/c, but not C57BL/6, mice, a large portion of thymic CD4(-)CD8(+) T cells exhibit a memory-like phenotype. In BALB/c mice, IL-4 secreted by invariant natural killer T (iNKT) cells is both essential and sufficient for the generation of memory-like T cells. In C57BL/6 mice, iNKT cells are less abundant, producing IL-4 that is insufficient to induce thymic memory-like CD8(+) T cells. BALB/c mice deficient in the transcription factor Kruppel-like factor (KLF) 13 have comparable numbers of iNKT cells to C57BL/6 mice and extremely low levels of thymic memory-like CD8(+) T cells. This work documents the impact of a small number of KLF13-dependent iNKT cells on the generation of memory-like CD8(+) T cells.

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