Synthesis and Biological Evaluation of Benzyl Styrylsulfonyl Derivatives As Potent Anticancer Mitotic Inhibitors

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2011 Apr 6

PMID 21463944

Citations 4

Authors

Osama Chahrour

Ashraf Abdalla

Frankie Lam

Carol Midgley

Shudong Wang

Affiliations

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Abstract

We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.

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