Cardiac Cell Therapy: the Next (re)generation

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2011 Mar 26

PMID 21437575

Citations 14

Authors

Elvira Forte

Isotta Chimenti

Lucio Barile

Roberto Gaetani

Francesco Angelini

Vittoria Ionta

Elisa Messina

Alessandro Giacomello

Affiliations

Soon will be listed here.

Abstract

Heart failure remains one of the main causes of morbidity and mortality in the Western world. Current therapies for myocardial infarction are mostly aimed at blocking the progression of the disease, preventing detrimental cardiac remodeling and potentiating the function of the surviving tissue. In the last decade, great interest has arisen from the possibility to regenerate lost tissue by using cells as a therapeutic tool. Different cell types have been tested in animal models, including bone marrow-derived cells, myoblasts, endogenous cardiac stem cells, embryonic cells and induced pluripotent stem cells. After the conflicting and often inconsistent results of the first clinical trials, a step backward needs to be performed, to understand the basic biological mechanisms underlying spontaneous and induced cardiac regeneration. Current studies aim at finding new strategies to enhance cellular homing, survival and differentiation in order to improve the overall outcome of cellular cardiomyoplasty.

Citing Articles

On the Road to Regeneration: "Tools" and "Routes" Towards Efficient Cardiac Cell Therapy for Ischemic Cardiomyopathy.

Pagano F, Picchio V, Chimenti I, Sordano A, De Falco E, Peruzzi M Curr Cardiol Rep. 2019; 21(11):133.

PMID: 31673821 DOI: 10.1007/s11886-019-1226-5.

The Biological Mechanisms of Action of Cardiac Progenitor Cell Therapy.

Pagano F, Picchio V, Angelini F, Iaccarino A, Peruzzi M, Cavarretta E Curr Cardiol Rep. 2018; 20(10):84.

PMID: 30105430 DOI: 10.1007/s11886-018-1031-6.

Normal versus Pathological Cardiac Fibroblast-Derived Extracellular Matrix Differentially Modulates Cardiosphere-Derived Cell Paracrine Properties and Commitment.

Pagano F, Angelini F, Castaldo C, Picchio V, Messina E, Sciarretta S Stem Cells Int. 2017; 2017:7396462.

PMID: 28740514 PMC: 5504962. DOI: 10.1155/2017/7396462.

Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up.

Chimenti I, Massai D, Morbiducci U, Beltrami A, Pesce M, Messina E J Cardiovasc Transl Res. 2017; 10(2):150-166.

PMID: 28289983 DOI: 10.1007/s12265-017-9741-5.

Β-blockers treatment of cardiac surgery patients enhances isolation and improves phenotype of cardiosphere-derived cells.

Chimenti I, Pagano F, Cavarretta E, Angelini F, Peruzzi M, Barretta A Sci Rep. 2016; 6:36774.

PMID: 27841293 PMC: 5107949. DOI: 10.1038/srep36774.

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