Getting to the Heart of the Matter: Direct Reprogramming to Cardiomyocytes

Overview

Journal Cell Stem Cell

Publisher Cell Press

Specialty Cell Biology

Date 2010 Aug 5

PMID 20682439

Citations 8

Authors

Robert Passier

Christine Mummery

Affiliations

Soon will be listed here.

Abstract

Since MyoD was used to convert fibroblasts directly to skeletal muscle, biologists have tried to apply this strategy to generate other cell lineages. In their recent Cell paper, Ieda et al. (2010) use selected cardiac transcription factors to directly reprogram fibroblasts to cardiomyocytes without passing through an intervening pluripotent state.

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