MDC1: The Art of Keeping Things in Focus

Overview

Journal Chromosoma

Specialty Molecular Biology

Date 2010 Mar 13

PMID 20224865

Citations 49

Authors

Stephanie Jungmichel

Manuel Stucki

Affiliations

Soon will be listed here.

Abstract

The chromatin structure is important for recognition and repair of DNA damage. Many DNA damage response proteins accumulate in large chromatin domains flanking sites of DNA double-strand breaks. The assembly of these structures-usually termed DNA damage foci-is primarily regulated by MDC1, a large nuclear mediator/adaptor protein that is composed of several distinct structural and functional domains. Here, we are summarizing the latest discoveries about the mechanisms by which MDC1 mediates DNA damage foci formation, and we are reviewing the considerable efforts taken to understand the functional implication of these structures.

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