Analysis of Additivity and Synergism in the Anti-plasmodial Effect of Purified Compounds from Plant Extracts

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2011 Mar 18

PMID 21411016

Citations 14

Authors

Eric Deharo

Hagai Ginsburg

Affiliations

Soon will be listed here.

Abstract

In the search for antimalarials from ethnobotanical origin, plant extracts are chemically fractionated and biological tests guide the isolation of pure active compounds. To establish the responsibility of isolated active compound(s) to the whole antiplasmodial activity of a crude extract, the literature in this field was scanned and results were analysed quantitatively to find the contribution of the pure compound to the activity of the whole extract. It was found that, generally, the activity of isolated molecules could not account on their own for the activity of the crude extract. It is suggested that future research should take into account the "drugs beside the drug", looking for those products (otherwise discarded along the fractionation process) able to boost the activity of isolated active compounds.

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