Delayed β-cell Response and Glucose Intolerance in Young Women with Turner Syndrome

Overview

Journal BMC Endocr Disord

Publisher Biomed Central

Specialty Endocrinology

Date 2011 Mar 17

PMID 21406078

Citations 17

Authors

Britta E Hjerrild

Jens J Holst

Claus B Juhl

Jens S Christiansen

Ole Schmitz

Claus H Gravholt

Affiliations

Soon will be listed here.

Abstract

Background: To investigate glucose homeostasis in detail in Turner syndrome (TS), where impaired glucose tolerance (IGT) and type 2 diabetes are frequent.

Methods: Cross sectional study of women with Turner syndrome (TS)(n = 13) and age and body mass index matched controls (C) (n = 13), evaluated by glucose tolerance (oral and intravenous glucose tolerance test (OGTT and IVGTT)), insulin sensitivity (hyperinsulinemic, euglycemic clamp), beta-cell function (hyperglycaemic clamp, arginine and GLP-1 stimulation) and insulin pulsatility.

Results: Fasting glucose and insulin levels were similar. Higher glucose responses was seen in TS during OGTT and IVGTT, persisting after correction for body weight or muscle mass, while insulin responses were similar in TS and C, despite the higher glucose level in TS, leading to an insufficient increase in insulin response during dynamic testing. Insulin sensitivity was comparable in the two groups (TS vs. control: 8.6 ± 1.8 vs. 8.9 ± 1.8 mg/kg*30 min; p = 0.6), and the insulin responses to dynamic β-cell function tests were similar. Insulin secretion patterns examined by deconvolution analysis, approximate entropy, spectral analysis and autocorrelation analysis were similar. In addition we found low IGF-I, higher levels of cortisol and norepinephrine and an increased waist-hip ratio in TS.

Conclusions: Young normal weight TS women show significant glucose intolerance in spite of normal insulin secretion during hyperglycaemic clamping and normal insulin sensitivity. We recommend regularly testing for diabetes in TS.

Trial Registration: Registered with http://clinicaltrials.com, ID nr: NCT00419107.

Citing Articles

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Clinical practice guidelines for the care of girls and women with Turner syndrome.

Gravholt C, Andersen N, Christin-Maitre S, Davis S, Duijnhouwer A, Gawlik A Eur J Endocrinol. 2024; 190(6):G53-G151.

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Screening for Turner Syndrome-Associated Hyperglycemia: Evaluating Hemoglobin A1c and Fasting Blood Glucose.

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Components of the metabolic syndrome in girls with Turner syndrome treated with growth hormone in a long term prospective study.

Blaszczyk E, Shulhai A, Gieburowska J, Baranski K, Gawlik A Front Endocrinol (Lausanne). 2023; 14:1216464.

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