Actovegin®: a Biological Drug for More Than 5 Decades

Overview

Journal Wien Med Wochenschr

Specialty General Medicine

Date 2011 Mar 16

PMID 21404144

Citations 12

Authors

Florian Buchmayer

Johannes Pleiner

Martin W Elmlinger

Gereon Lauer

Gerfried Nell

Harald H Sitte

Affiliations

Soon will be listed here.

Abstract

Actovegin(®) is a biological drug manufactured from a natural source: it is a calf blood hemodialysate. Its therapeutic benefits stem from a variety of pharmacodynamic actions that can be summarized to a common goal, i.e. the enhancement of cellular metabolism; this results from an insulin-like activity mediated by Inositol-phospho-oligosaccharides. Actovegin(®) results in beneficial effects in several pathophysiological clinical settings including malfunction of the blood circulation and trophic disturbances in the brain, impairment of peripheral blood circulation and associated diseases, dermal transplants and acute and chronic wounds. Here, we give an overview of the pharmacodynamic actions of calf-blood hemidialysate and its beneficial effects in a variety of clinical settings.

Citing Articles

The Physiological and Performance Effects of Actovegin during Maximal Cardiopulmonary Exercise Testing: A Randomized, Double-Blind, Placebo-Controlled Trial.

Milovanovic D, Radovanovic D, Zivkovic V, Srejovic I, Glisic M, Jakovljevic V Nutrients. 2024; 16(19).

PMID: 39408298 PMC: 11478799. DOI: 10.3390/nu16193332.

Actovegin in the management of patients after ischemic stroke: A systematic review.

la Fleur P, Baizhaxynova A, Reynen E, Kaunelis D, Galiyeva D PLoS One. 2022; 17(6):e0270497.

PMID: 35771887 PMC: 9246213. DOI: 10.1371/journal.pone.0270497.

Neuroprotective Effects of Deproteinized Calf Serum in Ischemic Stroke.

Li W, Guo A, Sun M, Wang J, Wang Q Front Neurol. 2021; 12:636494.

PMID: 34557139 PMC: 8453072. DOI: 10.3389/fneur.2021.636494.

Actovegin® reduces PMA-induced inflammation on human cells.

Reichl F, Hogg C, Liu F, Schwarz M, Teupser D, Hickel R Eur J Appl Physiol. 2020; 120(7):1671-1680.

PMID: 32447451 PMC: 8497287. DOI: 10.1007/s00421-020-04398-2.

Current Synthesis and Systematic Review of Main Effects of Calf Blood Deproteinized Medicine (Actovegin) in Ischemic Stroke.

Firan F, Romila A, Onose G Int J Mol Sci. 2020; 21(9).

PMID: 32365943 PMC: 7246744. DOI: 10.3390/ijms21093181.

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