Design, Synthesis, and Evaluation of Coumarin-based Molecular Probes for Imaging of Myelination

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2011 Mar 12

PMID 21391687

Citations 17

Authors

Changning Wang

Chunying Wu

Junqing Zhu

Robert H Miller

Yanming Wang

Affiliations

Soon will be listed here.

Abstract

Myelination represents one of the most fundamental biological processes in the vertebrate nervous system. Abnormalities and changes in myelination in the central nervous system (CNS) are seen in many neurodegenerative disorders, such as multiple sclerosis (MS). A long-standing goal has been to directly detect and quantify myelin content in order to facilitate diagnosis and therapeutic treatments of myelin-related diseases. In the course of our studies, we have developed a series of small-molecule probes (SMP) as myelin-imaging agents. Among them are coumarin derivatives, which exhibit promising brain permeability and myelin-binding properties. Herein we report a full account of the design and synthesis of coumarin-based SMPs as myelin-imaging agents. Systematic evaluation of these SMPs in both the CNS and peripheral nervous system (PNS) allowed us to identify some lead agents for potential use as fluorescent dyes for intraoperative nerve mapping in surgical operations or as radiotracers for positron emission tomography (PET) imaging of myelination.

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