A Brief History of IL-9

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2011 Mar 4

PMID 21368237

Citations 208

Authors

Ritobrata Goswami

Mark H Kaplan

Affiliations

Soon will be listed here.

Abstract

IL-9 was first described in the late 1980s as a member of a growing number of cytokines that had pleiotropic functions in the immune system. Although many biological functions have been attributed to IL-9, it remains an understudied cytokine. A resurgence of interest in IL-9 has been spurred by recent work demonstrating a role for IL-9 in regulating inflammatory immunity and defining the transcription factors that activate the Il9 gene in cells that most efficiently produce IL-9. In this review, we summarize the characterization of IL-9 biological activities, highlight roles for the cytokine that are clearly defined, and outline questions regarding IL-9 functions that still require further exploration.

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