Prophylactic Vesical Instillations with 0.2% Chondroitin Sulfate May Reduce Symptoms of Acute Radiation Cystitis in Patients Undergoing Radiotherapy for Gynecological Malignancies

Overview

Journal Int Urogynecol J

Publisher Springer

Specialties Gynecology & Obstetrics
Urology

Date 2011 Mar 3

PMID 21365332

Citations 14

Authors

Menke H Hazewinkel

Lukas J A Stalpers

Marcel G Dijkgraaf

Jan-Paul W R Roovers

Affiliations

Soon will be listed here.

Abstract

Introduction And Hypothesis: We studied the feasibility and efficacy of intravesical instillations with 40 ml chondroitin sulfate 0.2% solution to prevent or reduce acute radiation cystitis in women undergoing pelvic radiotherapy.

Methods: In a comparative pilot study in 20 patients, half of the patients received instillations. Instillations' bother was measured with visual analog scores (VAS, 0-10); bladder pain, with VAS; micturition-related quality of life, with the urogenital distress inventory (UDI).

Results: One of the instilled patients discontinued the instillations. The first median "acceptability"-VAS was 0 (range, 0-3); the last median was 1 (range, 0-3). "Bladder pain"-VAS peaked halfway in the treatment among controls (median, 1; range, 0-5) and after treatment in the instilled patients (median, 1; range, 1-3). UDI scores showed over time median follow-up scores at or above median baseline scores in controls and at or below median baseline scores in instilled patients.

Conclusion: Intravesical instillations with chondroitin sulfate 0.2% solution may decrease the bother related to bladder symptoms and are well tolerated.

Citing Articles

Glycosaminoglycan Replacement Therapy with Intravesical Instillations of Combined Hyaluronic Acid and Chondroitin Sulfate in Patients with Recurrent Cystitis, Post-radiation Cystitis and Bladder Pain Syndrome: A Narrative Review.

Poletajew S, Brzozka M, Krajewski W, Kamecki H, Nyk L, Kryst P Pain Ther. 2023; 13(1):1-22.

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The efficacy and safety of intravesical chondroitin sulphate solution in recurrent urinary tract infections.

RahnamaI M, Javan Balegh Marand A, Roschmann-Doose K, Steffens L, Arendsen H BMC Urol. 2022; 22(1):188.

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Evaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in rats.

Nunes V, Vidigal P, Pereira M, Ladeira L, Caliari M, Oliveira F Acta Cir Bras. 2021; 36(8):e360805.

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Radiation-induced haemorrhagic cystitis after prostate cancer radiotherapy: factors associated to hospitalization and treatment strategies.

Sanguedolce F, Sancho Pardo G, Mercade Sanchez A, Lucena J, Pisano F, Cortez J Prostate Int. 2021; 9(1):48-53.

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Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives.

Helissey C, Cavallero S, Brossard C, Dusaud M, Chargari C, Francois S Cells. 2020; 10(1).

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