The Effect of Nicorandil on Small Intestinal Ischemia-reperfusion Injury in a Canine Model

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2011 Mar 2

PMID 21360281

Citations 5

Authors

Yujin Suto

Kiyohiro Oshima

Kazuhisa Arakawa

Hiroaki Sato

Hodaka Yamazaki

Koshi Matsumoto

Izumi Takeyoshi

Affiliations

Soon will be listed here.

Abstract

Background: It has been shown that nicorandil, which has both ATP-sensitive K+ (KATP) channel opener-like and nitrate-like properties, has an organ-protective effect in ischemia-reperfusion injury in several experimental animal models.

Aims: We evaluate the effectiveness of nicorandil on warm ischemia-reperfusion injury of the small intestine in a canine model.

Methods: Eighteen beagle dogs were divided into three groups: the control group (n=6); the nicorandil group (n=6), to which nicorandil was injected intravenously before the ischemia; and the glibenclamide group (n=6), to which glibenclamide, which closes the KATP channel and does not suppress the nitrate effect of nicorandil, was orally administered, and then nicorandil was injected in the same manner as in the nicorandil group. Both the superior mesenteric artery and vein were clamped for 2 h. Superior mesenteric artery blood flow, small intestinal mucosal tissue blood flow, intramucosal pH, and histopathological analyses were compared among the three groups.

Results: Superior mesenteric artery blood flow, mucosal tissue blood flow and pHi after reperfusion were significantly maintained in the nicorandil in comparison with the control and the glibenclamide groups. The histopathological findings showed less severe mucosal damage after reperfusion in the nicorandil group compared with the other two groups. Between the control group and the glibenclamide group, no significant differences were observed in all those parameters.

Conclusion: This study suggests that nicorandil has a protective effect on small intestinal IR injury, and activation of KATP channels plays an important role in inhibiting small intestinal IR injury.

Citing Articles

Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia-reperfusion injury.

Archontakis-Barakakis P, Mavridis T, Chlorogiannis D, Barakakis G, Laou E, Sessler D Clin Transl Med. 2024; 15(1):e70136.

PMID: 39724463 PMC: 11670310. DOI: 10.1002/ctm2.70136.

Establishment of an acute arterial mesenteric ischaemia model in canines with an endovascular approach.

Shi Y, Zhou Y, Yuan Y, Kong J, Gong M, Chen L Front Vet Sci. 2024; 11:1373914.

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Therapeutic potential of nicorandil beyond anti-anginal drug: A review on current and future perspectives.

Singh D, Singh R, Akindele A Heliyon. 2024; 10(7):e28922.

PMID: 38617945 PMC: 11015415. DOI: 10.1016/j.heliyon.2024.e28922.

Computed Tomography Perfusion Imaging Detection of Microcirculatory Dysfunction in Small Intestinal Ischemia-Reperfusion Injury in a Porcine Model.

Shi H, Li R, Qiang J, Li Y, Wang L, Sun R PLoS One. 2016; 11(7):e0160102.

PMID: 27458696 PMC: 4961382. DOI: 10.1371/journal.pone.0160102.

Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research.

Gonzalez L, Moeser A, Blikslager A Am J Physiol Gastrointest Liver Physiol. 2014; 308(2):G63-75.

PMID: 25414098 PMC: 4297854. DOI: 10.1152/ajpgi.00112.2013.

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