Cephalometric Features in Isolated Growth Hormone Deficiency

Overview

Journal Angle Orthod

Specialty Dentistry

Date 2011 Feb 24

PMID 21341997

Citations 8

Authors

Luiz Alves Oliveira-Neto

Mariade de Fatima B Melo

Alexandre A Franco

Alaide H A Oliveira

Anita H O Souza

Eugenia H O Valenca

Isabela M P A Britto

Roberto Salvatori

Manuel H Aguiar-Oliveira

Affiliations

Soon will be listed here.

Abstract

Objective: To analyze cephalometric features in adults with isolated growth hormone (GH) deficiency (IGHD).

Materials And Methods: Nine adult IGHD individuals (7 males and 2 females; mean age, 37.8 ± 13.8 years) underwent a cross-sectional cephalometric study, including 9 linear and 5 angular measurements. Posterior facial height/anterior facial height and lower-anterior facial height/anterior facial height ratios were calculated. To pool cephalometric measurements in both genders, results were normalized by standard deviation scores (SDS), using the population means from an atlas of the normal Brazilian population.

Results: All linear measurements were reduced in IGHD subjects. Total maxillary length was the most reduced parameter (-6.5 ± 1.7), followed by a cluster of six measurements: posterior cranial base length (-4.9 ± 1.1), total mandibular length (-4.4 ± 0.7), total posterior facial height (-4.4 ± 1.1), total anterior facial height (-4.3 ± 0.9), mandibular corpus length (-4.2 ± 0.8), and anterior cranial base length (-4.1 ± 1.7). Less affected measurements were lower-anterior facial height (-2.7 ± 0.7) and mandibular ramus height (-2.5 ± 1.5). SDS angular measurements were in the normal range, except for increased gonial angle (+2.5 ± 1.1). Posterior facial height/anterior facial height and lower-anterior facial height/anterior facial height ratios were not different from those of the reference group.

Conclusions: Congenital, untreated IGHD causes reduction of all linear measurements of craniofacial growth, particularly total maxillary length. Angular measurements and facial height ratios are less affected, suggesting that lGHD causes proportional blunting of craniofacial growth.

Citing Articles

Cephalometric Evaluation of Children with Short Stature of Genetic Etiology: A Review.

Paltoglou G, Ziakas N, Chrousos G, Yapijakis C Children (Basel). 2024; 11(7).

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Effects of endocrine disorders on maxillary and mandibular growth in Colombian children and adolescents: a cross-sectional study.

Alfaro J, Manrique R, Santamaria A, Alvarez E, Manes C, Jimenez M Eur Arch Paediatr Dent. 2023; 25(1):17-25.

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The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome.

Aguiar-Oliveira M, Salvatori R Arch Endocrinol Metab. 2022; 66(6):919-928.

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Art and science: impact of semioccluded vocal tract exercises and choral singing on quality of life in subjects with congenital GH deficiency.

de Andrade B, Valenca E, Salvatori R, Oliveira Neto L, Souza A, Oliveira A Arch Endocrinol Metab. 2022; 66(2):198-205.

PMID: 35315986 PMC: 9832885. DOI: 10.20945/2359-3997000000449.

Disruption of the GHRH receptor and its impact on children and adults: The Itabaianinha syndrome.

Aguiar-Oliveira M, Salvatori R Rev Endocr Metab Disord. 2020; 22(1):81-89.

PMID: 32935264 DOI: 10.1007/s11154-020-09591-4.

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