JNK Regulates FoxO-dependent Autophagy in Neurons

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2011 Feb 18

PMID 21325132

Citations 138

Authors

Ping Xu

Madhumita Das

Judith Reilly

Roger J Davis

Affiliations

Soon will be listed here.

Abstract

The cJun N-terminal kinase (JNK) signal transduction pathway is implicated in the regulation of neuronal function. JNK is encoded by three genes that play partially redundant roles. Here we report the creation of mice with targeted ablation of all three Jnk genes in neurons. Compound JNK-deficient neurons are dependent on autophagy for survival. This autophagic response is caused by FoxO-induced expression of Bnip3 that displaces the autophagic effector Beclin-1 from inactive Bcl-XL complexes. These data identify JNK as a potent negative regulator of FoxO-dependent autophagy in neurons.

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