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Epigenetic Changes in Individuals with Arsenicosis

Overview
Journal Chem Res Toxicol
Publisher American Chemical Society
Specialty Toxicology
Date 2011 Feb 5
PMID 21291286
Citations 71
Authors
Lisa Smeester
Julia E Rager
Kathryn A Bailey
Xiaojun Guan
Nikia Smith
Gonzalo Garcia-Vargas
Luz-Maria Del Razo
Zuzana Drobna
Hemant Kelkar
Miroslav Styblo
Rebecca C Fry
Affiliations
Soon will be listed here.
Abstract

Inorganic arsenic (iAs) is an environmental toxicant currently poisoning millions of people worldwide, and chronically exposed individuals are susceptible to arsenicosis or arsenic poisoning. Using a state-of-the-art technique to map the methylomes of our study subjects, we identified a large interactome of hypermethylated genes that are enriched for their involvement in arsenic-associated diseases, such as cancer, heart disease, and diabetes. Notably, we have uncovered an arsenic-induced tumor suppressorome, a complex of 17 tumor suppressors known to be silenced in human cancers. This finding represents a pivotal clue in unraveling a possible epigenetic mode of arsenic-induced disease.

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