Investigating the Pathobiology of Alcoholic Pancreatitis

Overview

Journal Alcohol Clin Exp Res

Specialty Psychiatry

Date 2011 Feb 3

PMID 21284675

Citations 27

Authors

Stephen J Pandol

Aurelia Lugea

Olga A Mareninova

Duane Smoot

Fred S Gorelick

Anna S Gukovskaya

Ilya Gukovsky

Affiliations

Soon will be listed here.

Abstract

Alcohol abuse is one of the most common causes of pancreatitis. The risk of developing alcohol-induced pancreatitis is related to the amount and duration of drinking. However, only a small portion of heavy drinkers develop disease, indicating that other factors (genetic, environmental, or dietary) contribute to disease initiation. Epidemiologic studies suggest roles for cigarette smoking and dietary factors in the development of alcoholic pancreatitis. The mechanisms underlying alcoholic pancreatitis are starting to be understood. Studies from animal models reveal that alcohol sensitizes the pancreas to key pathobiologic processes that are involved in pancreatitis. Current studies are focussed on the mechanisms responsible for the sensitizing effect of alcohol; recent findings reveal disordering of key cellular organelles including endoplasmic reticulum, mitochondria, and lysosomes. As our understanding of alcohol's effects continue to advance to the level of molecular mechanisms, insights into potential therapeutic strategies will emerge providing opportunities for clinical benefit.

Citing Articles

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Recent insights about autophagy in pancreatitis.

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β-Carotene Supplementation Improves Pancreas Function during Moderate Ethanol Consumption: Initial Characterization from a Morphological Overview.

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Ethanol inhibits pancreatic acinar cell autophagy through upregulation of ATG4B, mediating pathological responses of alcoholic pancreatitis.

Mareninova O, Gretler S, Lee G, Pimienta M, Qin Y, Elperin J Am J Physiol Gastrointest Liver Physiol. 2023; 325(3):G265-G278.

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Li J, Li Y, Chen C, Guo J, Qiao M, Lyu J Front Med (Lausanne). 2022; 9:1049136.

PMID: 36569146 PMC: 9773388. DOI: 10.3389/fmed.2022.1049136.

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