Anna S Gukovskaya
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Explore the profile of Anna S Gukovskaya including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Gukovskaya A, Lerch M, Mayerle J, Sendler M, Ji B, Saluja A, et al.
World J Gastroenterol
. 2024 Nov;
30(41):4417-4438.
PMID: 39534420
Pancreatitis is a common, life-threatening inflammatory disease of the exocrine pancreas. Its pathogenesis remains obscure, and no specific or effective treatment is available. Gallstones and alcohol excess are major etiologies...
2.
Mareninova O, Gretler S, Lee G, Pimienta M, Qin Y, Elperin J, et al.
Am J Physiol Gastrointest Liver Physiol
. 2023 Jul;
325(3):G265-G278.
PMID: 37431575
Excessive alcohol intake is a major risk factor for pancreatitis, sensitizing the exocrine pancreas to stressors by mechanisms that remain obscure. Impaired autophagy drives nonalcoholic pancreatitis, but the effects of...
3.
Mareninova O, Dillon D, Wightman C, Yakubov I, Takahashi T, Gaisano H, et al.
Cell Mol Gastroenterol Hepatol
. 2021 Oct;
13(2):599-622.
PMID: 34610499
Background: Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small...
4.
Mareninova O, Vegh E, Shalbueva N, Wightman C, Dillon D, Malla S, et al.
J Clin Invest
. 2021 Jun;
131(15.
PMID: 34128834
Disordered lysosomal/autophagy pathways initiate and drive pancreatitis, but the underlying mechanisms and links to disease pathology are poorly understood. Here, we show that the mannose-6-phosphate (M6P) pathway of hydrolase delivery...
5.
Williams J, Groblewski G, Gorelick F, Mayerle J, Apte M, Gukovskaya A
Pancreas
. 2020 May;
49(5):604-611.
PMID: 32433396
No abstract available.
6.
Mareninova O, Jia W, Gretler S, Holthaus C, Thomas D, Pimienta M, et al.
Autophagy
. 2020 Jan;
16(11):2084-2097.
PMID: 31942816
Pancreatitis is a common, sometimes fatal, disease of exocrine pancreas, initiated by damaged acinar cells. Recent studies implicate disordered macroautophagy/autophagy in pancreatitis pathogenesis. ATG8/LC3 protein is critical for autophagosome formation...
7.
Malla S, Krueger B, Wartmann T, Sendler M, Mahajan U, Weiss F, et al.
Cell Mol Life Sci
. 2019 Aug;
77(9):1811-1825.
PMID: 31363815
Premature intrapancreatic trypsinogen activation is widely regarded as an initiating event for acute pancreatitis. Previous studies have alternatively implicated secretory vesicles, endosomes, lysosomes, or autophagosomes/autophagolysosomes as the primary site of...
8.
Gukovskaya A, Gorelick F, Groblewski G, Mareninova O, Lugea A, Antonucci L, et al.
Pancreas
. 2019 Apr;
48(4):459-470.
PMID: 30973461
Acute pancreatitis (AP) is a potentially lethal inflammatory disease that lacks specific therapy. Damaged pancreatic acinar cells are believed to be the site of AP initiation. The primary function of...
9.
Habtezion A, Gukovskaya A, Pandol S
Gastroenterology
. 2019 Jan;
156(7):1941-1950.
PMID: 30660726
Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with tissue injury and necrosis. The disease can be mild, involving only the pancreas, and resolve spontaneously within days...
10.
Abu-El-Haija M, Gukovskaya A, Andersen D, Gardner T, Hegyi P, Pandol S, et al.
Pancreas
. 2018 Oct;
47(10):1185-1192.
PMID: 30325856
A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities on drug development for pancreatitis. This conference was...