The IL1alpha-S100A13 Heterotetrameric Complex Structure: a Component in the Non-classical Pathway for Interleukin 1alpha Secretion

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2011 Jan 29

PMID 21270123

Citations 16

Authors

Sepuru K Mohan

Chin Yu

Affiliations

Soon will be listed here.

Abstract

Interleukin 1α (IL1α) plays an important role in several key biological functions, such as angiogenesis, cell proliferation, and tumor growth in several types of cancer. IL1α is a potent cytokine that induces a wide spectrum of immunological and inflammatory activities. The biological effects of IL1α are mediated through the activation of transmembrane receptors (IL1Rs) and therefore require the release of the protein into the extracellular space. IL1α is exported through a non-classical release pathway involving the formation of a specific multiprotein complex, which includes IL1α and S100A13. Because IL1α plays an important role in cell proliferation and angiogenesis, inhibiting the formation of the IL1α-S100A13 complex would be an effective strategy to inhibit a wide range of cancers. To understand the molecular events in the IL1α release pathway, we studied the structure of the IL1α-S100A13 tetrameric complex, which is the key complex formed during the non-classical pathway of IL1α release.

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References

Shin J, Opalenik S, Wehby J, Mahesh V, Jackson A, Tarantini F . Serum-starvation induces the extracellular appearance of FGF-1. Biochim Biophys Acta. 1996; 1312(1):27-38. DOI: 10.1016/0167-4889(96)00013-4. View

Diaz A, Stephenson S, Green J, Levdikov V, Wilkinson A, Perego M . Functional role for a conserved aspartate in the Spo0E signature motif involved in the dephosphorylation of the Bacillus subtilis sporulation regulator Spo0A. J Biol Chem. 2007; 283(5):2962-72. DOI: 10.1074/jbc.M709032200. View

Chang H, Mohan S, Chin Y . 1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha. Biomol NMR Assign. 2010; 4(1):59-60. DOI: 10.1007/s12104-010-9207-z. View

Pomorski T, Hrafnsdottir S, Devaux P, van Meer G . Lipid distribution and transport across cellular membranes. Semin Cell Dev Biol. 2001; 12(2):139-48. DOI: 10.1006/scdb.2000.0231. View

Sivaraja V, Kumar T, Rajalingam D, Graziani I, Prudovsky I, Yu C . Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Biophys J. 2006; 91(5):1832-43. PMC: 1544301. DOI: 10.1529/biophysj.105.079988. View

Landriscina M, Bagala C, Mandinova A, Soldi R, Micucci I, Bellum S . Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. J Biol Chem. 2001; 276(27):25549-57. DOI: 10.1074/jbc.M102925200. View

Prudovsky I, Mandinova A, Soldi R, Bagala C, Graziani I, Landriscina M . The non-classical export routes: FGF1 and IL-1alpha point the way. J Cell Sci. 2003; 116(Pt 24):4871-81. DOI: 10.1242/jcs.00872. View

Fischer K, Voelkl S, Berger J, Andreesen R, Pomorski T, Mackensen A . Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells. Blood. 2006; 108(13):4094-101. DOI: 10.1182/blood-2006-03-011742. View

Shishibori T, Oyama Y, Matsushita O, Yamashita K, Furuichi H, Okabe A . Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. Biochem J. 1999; 338 ( Pt 3):583-9. PMC: 1220090. View

10.

Dayer J . The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis. Rheumatology (Oxford). 2003; 42 Suppl 2:ii3-10. DOI: 10.1093/rheumatology/keg326. View

11.

Grzesiek S, Bax A . Amino acid type determination in the sequential assignment procedure of uniformly 13C/15N-enriched proteins. J Biomol NMR. 1993; 3(2):185-204. DOI: 10.1007/BF00178261. View

12.

Hall D, Vander Kooi C, Stasik C, Stevens S, Zuiderweg E, Matthews R . Mapping the interactions between flavodoxin and its physiological partners flavodoxin reductase and cobalamin-dependent methionine synthase. Proc Natl Acad Sci U S A. 2001; 98(17):9521-6. PMC: 55485. DOI: 10.1073/pnas.171168898. View

13.

Nickel W . The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes. Eur J Biochem. 2003; 270(10):2109-19. DOI: 10.1046/j.1432-1033.2003.03577.x. View

14.

Mouta Carreira C, Nasser S, Di Tomaso E, Padera T, Boucher Y, Tomarev S . LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res. 2001; 61(22):8079-84. View

15.

Wand A, Englander S . Protein complexes studied by NMR spectroscopy. Curr Opin Biotechnol. 1996; 7(4):403-8. PMC: 3442359. DOI: 10.1016/s0958-1669(96)80115-7. View

16.

Linge J, ODonoghue S, Nilges M . Automated assignment of ambiguous nuclear overhauser effects with ARIA. Methods Enzymol. 2001; 339:71-90. DOI: 10.1016/s0076-6879(01)39310-2. View

17.

Kawaguchi Y, Nishimagi E, Tochimoto A, Kawamoto M, Katsumata Y, Soejima M . Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts. Proc Natl Acad Sci U S A. 2006; 103(39):14501-6. PMC: 1599989. DOI: 10.1073/pnas.0603545103. View

18.

Tarantini F, Micucci I, Bellum S, Landriscina M, Garfinkel S, Prudovsky I . The precursor but not the mature form of IL1alpha blocks the release of FGF1 in response to heat shock. J Biol Chem. 2000; 276(7):5147-51. DOI: 10.1074/jbc.C000714200. View

19.

Pierce A, Barron N, Linehan R, Ryan E, ODriscoll L, Daly C . Identification of a novel, functional role for S100A13 in invasive lung cancer cell lines. Eur J Cancer. 2007; 44(1):151-9. DOI: 10.1016/j.ejca.2007.10.017. View

20.

Cornilescu G, Delaglio F, Bax A . Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J Biomol NMR. 1999; 13(3):289-302. DOI: 10.1023/a:1008392405740. View