Interleukin-10 Promoter Polymorphism Predicts Initial Response of Chronic Hepatitis B to Interferon Alfa

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2011 Jan 22

PMID 21251301

Citations 16

Authors

Shaoyang Wang

Dedong Huang

Shunlai Sun

Weimin Ma

Qin Zhen

Affiliations

Soon will be listed here.

Abstract

In order to examine whether variation in interleukin-10 promoter polymorphism would predict the likelihood of sustain response of chronic hepatitis B to treatment with interferon alfa (IFN-α), the inheritance of 3 biallelic polymorphisms in the IL-10 gene promoter in patients with 52 chronic hepatitis B were determined by polymerase chain reaction (PCR)-bared techniques, restriction enzyme digestion or direct sequencing. The relationship to the outcome of antiviral therapy for chronic HBV infection was studied in 24 patients who had a virologically sustained response(SR) and in 28 non-responder(NR) to interferon alfa-2b and several IL-10 variants were more frequent among SR compared with NR. Carriage of the -592A allele, -592A/A genotype and -1082/-1819/-592 ATA haplotype was associated with SR. Our findings indicate that heterogeneity in the promoter region of the IL-10 gene has a role in determining the initial response of chronic hepatitis B to IFN-α therapy.

Citing Articles

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Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population.

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