Virus-replicating T Cells in the Immune Response of Mice. II. Characterization of T Cells Capable of Replicating Vesicular Stomatitis Virus

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1978 Oct 1

PMID 212507

Citations 8

Authors

N Minato

Y Katsura

Affiliations

Soon will be listed here.

Abstract

Immunocytological properties of the splenic T cell (Tv) which develop into virus plaque-forming cells in response to the antigenic challenge in vitro were investigated in relation to the properties of helper T cells and suppressor T cells in antibody response. Tv was observed in spleen around 1 wk after the intravenous injection of mice with 10(7) sheep erythrocytes. This contrasted with the finding that both helper T cells and suppressor T cells developed as early as 3 days after the immunization. Tv was proliferative in response to the antigenic stimulation, whereas helper T-cell activity could be expressed without cell division. Development of Tv to virus plaque-forming cells was much more dependent on macrophages than the generation of helper activity. Tv was found in nylon wool adherent fraction, whereas helper T cell was found in both nylon adherent and nonadherent fractions. Tv belongs to the short-lived and nonrecirculating T-cell population (T1), whereas the major part of helper T cells belongs to the long-lived and recirculating T-cell population (T2). These results strongly suggest that vesicular stomatitis virus infect and replicate in the different subset(s) of T cell(s) to which the major part of helper T cells belong.

Citing Articles

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High frequency detection of different T-cell subsets in mice by a modified virus plaque assay.

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The glycoprotein isolated from vesicular stomatitis virus is mitogenic for mouse B lymphocytes.

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Replication of vesicular stomatitis virus in mouse spleen cells.

Hecht T, Paul W Infect Immun. 1981; 32(3):1014-23.

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T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. II. Mechanism of the induction of suppressor T cells.

Kina T, Nishikawa S, Katsura Y Immunology. 1982; 46(3):583-7.

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