Tumour-initiating Stem-like Cells in Human Prostate Cancer Exhibit Increased NF-κB Signalling

Overview

Journal Nat Commun

Specialty Biology

Date 2011 Jan 20

PMID 21245843

Citations 155

Authors

Vinagolu K Rajasekhar

Lorenz Studer

William Gerald

Nicholas D Socci

Howard I Scher

Affiliations

Soon will be listed here.

Abstract

Androgen depletion is a key strategy for treating human prostate cancer, but the presence of hormone-independent cells escaping treatment remains a major therapeutic challenge. Here, we identify a minor subset of stem-like human prostate tumour-initiating cells (TICs) that do not express prostate cancer markers, such as androgen receptor or prostate specific antigen. These TICs possess stem cell characteristics and multipotency as demonstrated by in vitro sphere-formation and in vivo tumour-initiation, respectively. The cells represent an undifferentiated subtype of basal cells and can be purified from prostate tumours based on coexpression of the human pluripotent stem cell marker TRA-1-60 with CD151 and CD166. Such triple-marker-positive TICs recapitulate the original parent tumour heterogeneity in serial xeno-transplantations indicating a tumour cell hierarchy in human prostate cancer development. These TICs exhibit increased nuclear factor-κB activity. These findings are important in understanding the molecular basis of human prostate cancer.

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