Metabolism, Migration and Memory in Cytotoxic T Cells

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2011 Jan 15

PMID 21233853

Citations 139

Authors

David Finlay

Doreen A Cantrell

Affiliations

Soon will be listed here.

Abstract

The transcriptional and metabolic programmes that control CD8(+) T cells are regulated by a diverse network of serine/threonine kinases. The view has been that the kinases AKT and mammalian target of rapamycin (mTOR) control T cell metabolism. Here, we challenge this paradigm and discuss an alternative role for these kinases in CD8(+) T cells, namely to control cell migration. Another emerging concept is that AMP-activated protein kinase (AMPK) family members control T cell metabolism and determine the effector versus memory fate of CD8(+) T cells. We speculate that one link between metabolism and immunological memory is provided by kinases that originally evolved to control T cell metabolism and have subsequently acquired the ability to control the expression of key transcription factors that regulate CD8(+) T cell effector function and migratory capacity.

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