Prevalence of Human Coronaviruses in Adults with Acute Respiratory Tract Infections in Beijing, China

Overview

Journal J Med Virol

Specialty Microbiology

Date 2010 Dec 25

PMID 21181925

Citations 38

Authors

Lili Ren

Richard Gonzalez

Jin Xu

Yan Xiao

Yongjun Li

Hongli Zhou

Jianguo Li

Qingqing Yang

Jing Zhang

Lan Chen

Wei Wang

Guy Vernet

Glaucia Paranhos-Baccala

Zhong Wang

Jianwei Wang

Affiliations

Soon will be listed here.

Abstract

Human coronaviruses (HCoVs) are a common etiological agent of acute respiratory tract infections. HCoV infections, especially those caused by the two HCoVs identified most recently, NL63 and HKU-1, have not been characterized fully. To evaluate the prevalence and clinical presentations of HKU1 and NL63 in adults with acute respiratory tract infections, an investigation of HCoV infections in Beijing, China from 2005 to 2009 was performed by using reverse transcriptase PCR assays and sequencing analysis. Among 8,396 respiratory specimens studied, 87 (1%) clinical samples were positive for HCoVs, of which 50 samples (0.6% of the total) were positive for HCoV-OC43, 15 (0.2%) for HCoV-229E, 14 (0.2%) for HCoV-HKU1, and 8 (0.1%) for HCoV-NL63. The prevalence of HCoV infection in adults exhibited distinct seasonal fluctuations during the study period. In addition, patients positive for HCoV-229E infections were more likely to be co-infected with other respiratory viruses. Enterovirus, rhinovirus, and parainfluenza virus type 3 were the most common viruses found in patients with HCoV infections. The demographic and clinical data present in this study of HCoV infections in adults with acute respiratory tract infections should improve our understanding of the pathogenesis of HCoVs.

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