Interferon-gamma Induced Exacerbation of Systemic Lupus Erythematosus

Overview

Journal J Rheumatol

Specialty Rheumatology

Date 1990 Jun 1

PMID 2117660

Citations 20

Authors

K P Machold

J S Smolen

Affiliations

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Abstract

A patient with presumed rheumatoid arthritis based on clinical and serological evidence was subjected by her physician to interferon-gamma (IFN-gamma) therapy and developed a life threatening multiorgan flare of systemic lupus erythematosus (SLE). Pulse cyclophosphamide therapy in conjunction with plasmapheresis led to complete remission. Retrospective analysis of serum drawn before IFN-gamma was started revealed high DNA binding capacity. Thus, similar to observations in lupus-prone animals, IFN-gamma may have induced an exacerbation of preexisting SLE.

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