Clinical Use of Interferon-gamma

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2010 Jan 16

PMID 20074276

Citations 139

Authors

Catriona H T Miller

Stephen G Maher

Howard A Young

Affiliations

Soon will be listed here.

Abstract

Interferon gamma (IFN-gamma), a pleotropic cytokine, has been shown to be important to the function of virtually all immune cells and both innate and adaptive immune responses. In 1986, early clinical trials of this cytokine began to evaluate its therapeutic potential. The initial studies focused on the tolerability and pharmacology of IFN-gamma and systematically determined its antitumor and anti-infection activities. In the 20-plus years since those first trials, IFN-gamma has been used in a wide variety of clinical indications, which are reviewed in this article.

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References

RIDDELL L, Pinching A, Hill S, Ng T, Arbe E, Lapham G . A phase III study of recombinant human interferon gamma to prevent opportunistic infections in advanced HIV disease. AIDS Res Hum Retroviruses. 2001; 17(9):789-97. DOI: 10.1089/088922201750251981. View

Shapiro F, Glimcher M, Holtrop M, TASHJIAN Jr A, Kenzora J . Human osteopetrosis: a histological, ultrastructural, and biochemical study. J Bone Joint Surg Am. 1980; 62(3):384-99. View

Rinderknecht E, OConnor B, Rodriguez H . Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylation. J Biol Chem. 1984; 259(11):6790-7. View

Knutsen A, Hutchinson P, Albers G, Consolino J, Smick J, Kurup V . Increased sensitivity to IL-4 in cystic fibrosis patients with allergic bronchopulmonary aspergillosis. Allergy. 2003; 59(1):81-7. DOI: 10.1046/j.1398-9995.2003.00129.x. View

Soza A, Heller T, Ghany M, Lutchman G, Liang T, Germain J . Pilot study of interferon gamma for chronic hepatitis C. J Hepatol. 2005; 43(1):67-71. DOI: 10.1016/j.jhep.2005.02.023. View

Khalil N, OConnor R . Idiopathic pulmonary fibrosis: current understanding of the pathogenesis and the status of treatment. CMAJ. 2004; 171(2):153-60. PMC: 450366. DOI: 10.1503/cmaj.1030055. View

Selman M, Thannickal V, Pardo A, Zisman D, Martinez F, Lynch 3rd J . Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches. Drugs. 2004; 64(4):405-30. DOI: 10.2165/00003495-200464040-00005. View

Muir A, Sylvestre P, Rockey D . Interferon gamma-1b for the treatment of fibrosis in chronic hepatitis C infection. J Viral Hepat. 2006; 13(5):322-8. DOI: 10.1111/j.1365-2893.2005.00689.x. View

Shah N, Noble P, Jackson R, King Jr T, Nathan S, Padilla M . A critical assessment of treatment options for idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis. 2005; 22(3):167-74. PMC: 1550766. View

10.

Moss R, Mayer-Hamblett N, Wagener J, Daines C, Hale K, Ahrens R . Randomized, double-blind, placebo-controlled, dose-escalating study of aerosolized interferon gamma-1b in patients with mild to moderate cystic fibrosis lung disease. Pediatr Pulmonol. 2004; 39(3):209-18. DOI: 10.1002/ppul.20152. View

11.

Marciano B, Wesley R, De Carlo E, Anderson V, Barnhart L, Darnell D . Long-term interferon-gamma therapy for patients with chronic granulomatous disease. Clin Infect Dis. 2004; 39(5):692-9. DOI: 10.1086/422993. View

12.

Milanes-Virelles M, Garcia-Garcia I, Santos-Herrera Y, Valdes-Quintana M, Valenzuela-Silva C, Jimenez-Madrigal G . Adjuvant interferon gamma in patients with pulmonary atypical Mycobacteriosis: a randomized, double-blind, placebo-controlled study. BMC Infect Dis. 2008; 8:17. PMC: 2275277. DOI: 10.1186/1471-2334-8-17. View

13.

Key Jr L, Ries W, Rodriguiz R, HATCHER H . Recombinant human interferon gamma therapy for osteopetrosis. J Pediatr. 1992; 121(1):119-24. DOI: 10.1016/s0022-3476(05)82557-0. View

14.

Jimenez S, Hitraya E, Varga J . Pathogenesis of scleroderma. Collagen. Rheum Dis Clin North Am. 1996; 22(4):647-74. DOI: 10.1016/s0889-857x(05)70294-5. View

15.

Suarez-Mendez R, Garcia-Garcia I, Fernandez-Olivera N, Valdes-Quintana M, Milanes-Virelles M, Carbonell D . Adjuvant interferon gamma in patients with drug - resistant pulmonary tuberculosis: a pilot study. BMC Infect Dis. 2004; 4:44. PMC: 529257. DOI: 10.1186/1471-2334-4-44. View

16.

Fuss I, Neurath M, Boirivant M, Klein J, de La Motte C, Strong S . Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol. 1996; 157(3):1261-70. View

17.

Pujade-Lauraine E, Guastalla J, Colombo N, Devillier P, Francois E, Fumoleau P . Intraperitoneal recombinant interferon gamma in ovarian cancer patients with residual disease at second-look laparotomy. J Clin Oncol. 1996; 14(2):343-50. DOI: 10.1200/JCO.1996.14.2.343. View

18.

Chen C, Wu M, Chao K, Ho H, Sheu B, Huang S . T lymphocytes and cytokine production in ascitic fluid of ovarian malignancies. J Formos Med Assoc. 1999; 98(1):24-30. View

19.

Matsushita K, Takenouchi T, Shimada H, Tomonaga T, Hayashi H, Shioya A . Strong HLA-DR antigen expression on cancer cells relates to better prognosis of colorectal cancer patients: Possible involvement of c-myc suppression by interferon-gamma in situ. Cancer Sci. 2005; 97(1):57-63. PMC: 11158856. DOI: 10.1111/j.1349-7006.2006.00137.x. View

20.

Key Jr L, Rodriguiz R, Willi S, Wright N, HATCHER H, Eyre D . Long-term treatment of osteopetrosis with recombinant human interferon gamma. N Engl J Med. 1995; 332(24):1594-9. DOI: 10.1056/NEJM199506153322402. View